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Recombinant Human Adenosine receptor A3 (ADORA3)

  • 中文名稱:
  • 貨號:
    CSB-YP2844HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2844HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2844HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-BP2844HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-MP2844HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    AA3R
  • Uniprot No.:
  • 別名:
    Adenosine receptor A3 ADORA3
  • 種屬:
    Homo sapiens (Human)
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.
  • 基因功能參考文獻:
    1. Blockade of AAR decreases the differentiation of Glioblastoma stem-like cells to endothelial cells under hypoxia and in vivo blood vessel formation. PMID: 29670017
    2. Protein expression of TMIGD3 and A3AR is lower in human osteosarcoma tissues than normal tissues. Mechanistically, TMIGD3 isoform 1 and A3AR commonly inhibit the PKA-Akt-NF-kappaB axis. PMID: 27886186
    3. our results demonstrated that miR-206 has a proinflammatory role in UC by downregulating A3AR expression and activating NF-kappaB signalling. PMID: 27893428
    4. these findings propose that A3AR agonist induces cell cycle arrest and apoptosis in breast cancer stem cells by inhibition of ERK1/2 and GLI-1 cascade. PMID: 28230290
    5. Mast cells are directly activated by contact with cancer cell membranes by a mechanism involving autocrine formation of adenosine and autocrine/paracrine signaling of the adenosine A3 receptor. PMID: 28342985
    6. these data suggest that Cordyceps militaris hot water extracts containing cordycepin may be a promising treatment for bladder cancer via A3 adenosine receptor activation. PMID: 28714368
    7. Differential regulation in patients with LTP-induced anaphylaxis and those with NSAID-LTP-induced anaphylaxis of the IFN-gamma pathway, IgG receptors, and ADORA3 might provide the pathogenic basis of their distinct responses PMID: 26194548
    8. This study identifies human mast cell A3R as regulator of tissue remodeling gene expression in human mast cells and demonstrates a heretofore-unrecognized mode of feedback regulation that is exerted by this receptor. PMID: 25597247
    9. Effect of a toggle switch mutation in TM6 of the human adenosine A receptor on Gi protein-dependent signalling and Gi-independent receptor internalization PMID: 24750014
    10. Different agonistic behavior at adenosine A3 receptor is linked to a sub-pocket of the binding site. PMID: 24161786
    11. Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. PMID: 23817552
    12. There is differential expression of receptors in rheumatoid synovial tissue such that ADORA3 is expressed at significantly higher levels PMID: 22682496
    13. Activation of smooth muscle adenosine A(3) receptors increase proliferation of human coronary smooth cells. PMID: 22906537
    14. A3Rs play a role in neutrophil migration and disrupting this function has the potential to adversely affect innate immune responses. PMID: 23027555
    15. A3 receptor expression on the surface of PMNs is upregulated by injury, and increased expression levels are associated with greater injury severity and hypovolemic shock. PMID: 21841534
    16. Inactivation of the ADORA3 receptor prevents the CXCL16 effect of neuroprotection against excitotoxic damage. PMID: 22378888
    17. single-nucleotide polymorphism (SNP) I248L (reference SNP ID: rs35511654) located in the A3R gene is associated with coronary heart disease PMID: 21675873
    18. This study provides new insight into the spatial and temporal specificity of drug action that can be provided by allosteric modulation across a GPCR homodimeric interface. PMID: 21715680
    19. control of prostate cancer cell growth through A3 adenosine receptor activation. PMID: 21830157
    20. ADORA3 was expressed weakly in the cytoplasm of retinal pigment epithelium. PMID: 21542986
    21. results suggest that the high-transcript haplotype, ht1 (TC), of the ADORA3 gene may contribute to the development of cutaneous hyper-reactivity to aspirin, leading to the clinical presentation of aspirin-induced urticaria. PMID: 20716228
    22. testicular mouse A3Ri2 and human A3Ri3 adenosine receptors have roles in sperm function PMID: 20732875
    23. we show that A3 adenosine receptor/Gi3 play important roles in human mast cells responses initiated on contact with activated T cells. PMID: 20190146
    24. identification of residues in ligand recognition and activation PMID: 11891221
    25. involvement in adenosine inhibition of tissue factor expression by LPS-stimulated human monocytes PMID: 12152652
    26. A(3) receptors, in astrocytoma cells, are regulated after short- and long-term agonist exposure. PMID: 12435805
    27. using a rhodopsin-based molecular model of the A(3)AR to suggest multiple binding modes of the allosteric modulators. PMID: 12695530
    28. how RhoA activates phospholipase D to achieve the anti-ischemic effect of adenosine A3 receptors PMID: 14688204
    29. an in-depth investigation of A3 receptors in human lymphocytes and demonstrate that, under activating conditions, they are up-regulated and may contribute to the effects triggered by adenosine. PMID: 14978250
    30. effects of an A3AR agonist, IB-MECA, on the cell growth of human breast cancer cell lines suggest that the inhibitory effect of on the growth of human breast cancer cell lines is mediated through activation of A3 adenosine receptor. PMID: 15147729
    31. A(3)AR is expressed in tumors and may have a role in disease progression PMID: 15240539
    32. Elevated expression of A3 adenosine receptors is associated with colorectal cancer PMID: 15355922
    33. biophysical analysis of the effect of surfactants on human adenosine a3 receptor PMID: 15849244
    34. A3 receptor stimulation activates p44/p42 and p38 mitogen-activated protein kinases, which are required for A3-induced increase of HIF-1alpha and Ang-2 PMID: 16242072
    35. These data suggest that hypertonic saline upregulates polymorphonuclear neutrophil degranulation via ATP release and positive feedback through P2 and A3 receptors. PMID: 16282197
    36. Modulation of the adenosine A3 receptor on cord blood mononuclear cells polarizes toll- like receptor-mediated cytokine production during the perinatal period and may thereby modulate the newborn innate and adaptive immune responses. PMID: 16849509
    37. ATP release and autocrine feedback through P2Y2 and A3 receptors provide signal amplification, controlling gradient sensing and migration of neutrophils PMID: 17170310
    38. Overexpression of A3AR was found in PBMC of RA patients. Receptor upregulation was induced by inflammatory cytokines controlling the expression of the A3AR transcription factor NF-kappaB PMID: 17216675
    39. in colon cancer cell lines endogenous adenosine, through the interaction with A(3) receptors, mediates a tonic proliferative effect PMID: 17348028
    40. The A3 adenosine receptor is highly expressed in hepatocellular carcinoma (HCC)patients and might be a novel targeted therapy to treat HCC. PMID: 18636149
    41. Activation of the adenosine-A3 receptor stimulates matrix metalloproteinase-9 secretion by macrophages. PMID: 18653544
    42. when PBMC were stimulated with IFN-alpha, adenosine did not decrease, but synergistically increased, the IFN-gamma production of NK cells. This effect was also mediated mainly via the A(3) receptor PMID: 19095736
    43. NF-kappaB and CREB are involved with the over-expression of A(3)AR in patients with autoimmune inflammatory diseases. The receptor may be considered as a specific target to combat inflammation. PMID: 19426966

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  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level).
  • 數據庫鏈接:

    HGNC: 268

    OMIM: 600445

    KEGG: hsa:140

    UniGene: Hs.281342



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