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  4. Recombinant Human Acetyl-coenzyme A transporter 1 (SLC33A1), partial

Recombinant Human Acetyl-coenzyme A transporter 1 (SLC33A1), partial

  • 中文名稱：
    人SLC33A1重組蛋白
  • 貨號：
    CSB-YP021579HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SLC33A1重組蛋白
  • 貨號：
    CSB-EP021579HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SLC33A1重組蛋白
  • 貨號：
    CSB-EP021579HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SLC33A1重組蛋白
  • 貨號：
    CSB-BP021579HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SLC33A1重組蛋白
  • 貨號：
    CSB-MP021579HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC33A1
  • Uniprot No.：
  • 別名：
    ACATN; ACATN_HUMAN; Acetyl CoA transporter; Acetyl Coenzyme A transporter; Acetyl coenzyme A transporter 1; Acetyl-CoA transporter 1; Acetyl-coenzyme A transporter 1; AT 1; AT-1; AT1; Human Angiotensin II Type 1 Receptor; Slc33a1; Solute carrier family 33 (acetyl CoA transporter) member 1; Solute carrier family 33 member 1; spastic paraplegia 42 (autosomal dominant); SPG42
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides. Negatively regulates BMP signaling.
  • 基因功能參考文獻(xiàn)：
    1. results indicate that increased expression of AT-1 can cause an autistic-like phenotype by affecting key neuronal metabolic pathways. PMID: 27242167
    2. SLC33A1 can negatively regulate BMP signaling. PMID: 25402622
    3. Homozygosity mapping displayed a region of commonality among three families at chromosome 3q25. Deep sequencing and conventional sequencing disclosed homozygous or compound heterozygous mutations for all affected subjects in SLC33A1. PMID: 22243965
    4. translocates acetyl-CoA into the ER lumen and is essential for cell viability PMID: 20826464
    5. A missense mutation in SLC33A1 causes autosomal-dominant spastic paraplegia. PMID: 19061983

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  • 相關(guān)疾?。?/div>
    Spastic paraplegia 42, autosomal dominant (SPG42); Congenital cataracts, hearing loss, and neurodegeneration (CCHLND)
  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    SLC33A transporter family
  • 組織特異性：
    Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. With strongest signals in pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 95

    OMIM: 603690

    KEGG: hsa:9197

    STRING: 9606.ENSP00000352456

    UniGene: Hs.478031



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