在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)

Recombinant Human Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)

  • 中文名稱：
    Recombinant Human Acetyl-CoA acetyltransferase, mitochondrial(ACAT1)
  • 貨號(hào)：
    CSB-YP001134HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Acetyl-CoA acetyltransferase, mitochondrial(ACAT1)
  • 貨號(hào)：
    CSB-EP001134HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Acetyl-CoA acetyltransferase, mitochondrial(ACAT1)
  • 貨號(hào)：
    CSB-BP001134HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Acetyl-CoA acetyltransferase, mitochondrial(ACAT1)
  • 貨號(hào)：
    CSB-MP001134HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ACAT1
  • Uniprot No.：
  • 別名：
    ACAT 1; ACAT; acat1; Acetoacetyl CoA thiolase; acetoacetyl Coenzyme A thiolase; Acetoacetyl-CoA thiolase; Acetyl CoA acetyltransferase; mitochondrial ; Acetyl Coenzyme A acetyltransferase 1; Acetyl-CoA acetyltransferase; acetyl-coa acetyltransferase precursor; mitochondrial ; Acetyl-CoA thiolase; mitochondrial; acetyl-Coenzyme A acetyltransferase 1; MAT; mitochondrial acetoacetyl-CoA thiolase; mitochondrial; RATACAL; T2; testicular tissue protein Li 198; THIL; THIL_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    34-427
  • 氨基酸序列
    VSKPTLK EVVIVSATRT PIGSFLGSLS LLPATKLGSI AIQGAIEKAG IPKEEVKEAY MGNVLQGGEG QAPTRQAVLG AGLPISTPCT TINKVCASGM KAIMMASQSL MCGHQDVMVA GGMESMSNVP YVMNRGSTPY GGVKLEDLIV KDGLTDVYNK IHMGSCAENT AKKLNIARNE QDAYAINSYT RSKAAWEAGK FGNEVIPVTV TVKGQPDVVV KEDEEYKRVD FSKVPKLKTV FQKENGTVTA ANASTLNDGA AALVLMTADA AKRLNVTPLA RIVAFADAAV EPIDFPIAPV YAASMVLKDV GLKKEDIAMW EVNEAFSLVV LANIKMLEID PQKVNINGGA VSLGHPIGMS GARIVGHLTH ALKQGEYGLA SICNGGGGAS AMLIQKL
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism.
  • 基因功能參考文獻(xiàn)：
    1. High ACAT1 expression is associated with breast cancer. PMID: 30092298
    2. Insulin promotes progression of colon cancer by upregulation of ACAT1. PMID: 29793481
    3. ACAT1 exonic mutations that affect ESE sequences may result in aberrant splicing. This may affect the activity of mitochondrial acetoacetyl-CoA thiolase. PMID: 27748876
    4. compound heterozygous of ACAT1 gene mutations probably underlie the beta-ketothiolase deficiency in our patient PMID: 27264805
    5. Data indicate that acetyl-CoA acetyltransferase (ACAT1) and malate dehydrogenase (MDH2) are involved in various drug-resistance-forming mechanisms. PMID: 25639359
    6. the pyruvate dehydrogenase complex is regulated by Tyr phosphorylation of PDP1, which toggles recruitment between ACAT1 and SIRT3 PMID: 24486017
    7. these findings indicate that ACAT1 expression could serve as a potential prognostic marker in prostate cancer, specifically in differentiating indolent and aggressive forms of cancer. PMID: 24311408
    8. ACAT1 expression is substantially elevated in human castration-resistant metastatic prostate cancer tissues. PMID: 23443136
    9. Data show that the ketone body metabolizing enzymes BDH1, BDH2, OXCT1 and ACAT1 were expressed at the mRNA and protein level in all glioma cell lines. PMID: 21791085
    10. We herein identified a common mutation, R208X, in Vietnamese patients. We identified R208X homozygously in six patients and heterozygously in two patients among eight Vietnamese patients. PMID: 20156697
    11. the siblings with the same T2 gene mutations present different clinical severity of T2 deficiency PMID: 20046049
    12. Single base substitutions at the initiator codon produced wild-type T2 polypeptide to various degrees PMID: 12754704
    13. mild mutations (A132G, D339-V340insD) retained some residual T2 activity PMID: 15128923
    14. Cloning and sequencing long range PCR products revealed a 6.4kb deletion. Alu element-mediated unequal homologous recombination between an Alu-Sx in intron 1 and another Alu-Y in intron 4 appears to be responsible for this deletion. PMID: 16935016
    15. E252del is a temperature-sensitive K(m) mutant. PMID: 17236799
    16. Crystallographic and kinetic studies were made on mitochondrial acetyl-CoA thiolase: the importance of potassium and chloride ions were noted for its structure and function. PMID: 17371050
    17. A point mutation was responsible for the aberrant RNA splicing of the mitochondrial acetoacetyl-CoA thiolase gene. PMID: 18511318
    18. sequence recognition by the catalytic domain differs between hT2 and hT10 in that hT10 requires a pre-existing GalNAc residue while hT2 does not PMID: 18562306
    19. I/D polymorphism of ACE gene and AC AT1 gene influence the development of hypertension and Left Ventricular Hypertrophy in Hemodialysis patients. PMID: 19112833

    顯示更多

    收起更多

  • 相關(guān)疾病：
    3-ketothiolase deficiency (3KTD)
  • 亞細(xì)胞定位：
    Mitochondrion.
  • 蛋白家族：
    Thiolase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 93

    OMIM: 203750

    KEGG: hsa:38

    STRING: 9606.ENSP00000265838

    UniGene: Hs.232375



主站蜘蛛池模板： 在线播放五十路熟妇| 久久久精品456亚洲影院| 成人一在线视频日韩国产| 国产美女遭强高潮网站下载| 国产欧美精品一区二区三区四区| 51国偷自产一区二区三区| 久久人人爽人人爽人人片av麻烦| 亚洲乱码日产精品bd在线看 | 久久天天躁狠狠躁夜夜躁2012| 一区二区在线 | 国| 性高朝久久久久久久久久| 巨大黑人极品videos精品| 亚洲人成精品久久久久桥| 国产清纯美女爆白浆视频| 久久高清超碰av热热久久| 精品无码久久久久国产| 老熟妇高潮一区二区三区| 无码中文av有码中文a| 国产啪精品视频网站免| 久久久久人妻一区精品色| 国产成人精品无码片区在线观看| 久久婷婷综合激情亚洲狠狠| 国产在线清纯极品美女援交| 无尺码精品产品网站| 国产免费无遮挡吸奶头视频| 国产农村乱人伦精品视频| 成人a大片在线观看| 久热在线播放中文字幕| 国产精品偷伦视频免费观看了| 国产爆乳美女娇喘呻吟| 18处破外女出血在线| 蜜臀av片在线观看| 无码人妻h动漫| 看全色黄大色大片免费久久| 无码av动漫精品一区二区免费| 久久精品亚洲综合专区| 99久久久精品免费观看国产| 亚洲第一成人网站在线播放| 国产成 人 综合 亚洲专区| 少妇的渴望hd高清在线播放| 中文字幕日韩一区二区三区不卡 |