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  4. Recombinant Human ATP-binding cassette sub-family C member 9 (ABCC9), partial

Recombinant Human ATP-binding cassette sub-family C member 9 (ABCC9), partial

  • 中文名稱：
    Recombinant Human ATP-binding cassette sub-family C member 9(ABCC9) ,partial
  • 貨號：
    CSB-YP001067HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human ATP-binding cassette sub-family C member 9(ABCC9) ,partial
  • 貨號：
    CSB-EP001067HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human ATP-binding cassette sub-family C member 9(ABCC9) ,partial
  • 貨號：
    CSB-EP001067HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human ATP-binding cassette sub-family C member 9(ABCC9) ,partial
  • 貨號：
    CSB-BP001067HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human ATP-binding cassette sub-family C member 9(ABCC9) ,partial
  • 貨號：
    CSB-MP001067HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ABC37; abcC9; ABCC9_HUMAN; AI414027; AI449286; ATFB12; ATP-binding cassette sub-family C member 9; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette; sub-family C (CFTR/MRP); member 9; CANTU; CMD1O; FLJ36852; Sulfonylurea receptor 2; Sulfonylurea-binding protein 2; SUR2; SUR2A; SUR2B
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
  • 基因功能參考文獻：
    1. Significant gene-based association between the ABCC9 gene and hippocampal sclerosis-aging appeared to be driven by a region in which a significant haplotype-based association. PMID: 28131462
    2. ABCC9 gene has been associated with Dilated Cardiomyopathy. 3 pathogenic variants have been associated with DCM: 1 missense -CM1410876-, 1 nonsense -CM040975-, and 1 small indel -CX041212. PMID: 27736720
    3. Analysis of three Cantu syndrome-associated gain of function mutations indicates that all lead to overactive K(ATP) channels, but at least two mechanisms underlie the observed gain of function: decreased ATP inhibition and enhanced MgADP activation. PMID: 26621776
    4. The patient reported here gives further evidence that these syndromes are an expression of the ABCC9-related disorders, ranging from hypertrichosis and acromegaloid facies to the severe end of Cantu syndrome. PMID: 26871653
    5. ABCC9 polymorphism associated with Brain disorders: sleep problems. depression and HS-Aging. PMID: 26226329
    6. single amino acid difference can account for the markedly different diazoxide sensitivities between channels containing either the SUR1 or SUR2A subunit isoforms. PMID: 26181369
    7. We describe novel ABCC9 variants in human brain, corresponding to altered 3'UTR length, which could lead to targeting by miR-30c PMID: 26115089
    8. Results show that a polymorphism in ABCC9 is associated with aging pathology, and exposure to sulfonylurea drugs is associated with increased risk for aging pathology among individuals who died age 85 and older PMID: 24770881
    9. This study confirmed that specific ABCC9 single-nucleotide polymorphisms is associated with HS-Aging pathology in the Alzheimer disease. PMID: 25470345
    10. ABCC9 is a susceptibility gene for early repolarization syndrome and Brugada syndrome. PMID: 24439875
    11. A mutation (V734I) in ABCC9 increases susceptibility to coronary spasm and acute myocardial infarction. PMID: 23739550
    12. two different de novo missense mutations in the two patients with coarse facial features and hypertrichosis PMID: 23307537
    13. This study showed that variants in the SUR2 gene (ABCC9) associate with epidemiological variation in human sleep duration, which is also influenced by inter-individual differences in seasonal adaptation and chronotype. PMID: 22105623
    14. Electrophysiological experiments show that mutations in ABCC9, associated with Cantu syndrome, reduce the ATP-mediated potassium channel inhibition, resulting in channel opening. PMID: 22610116
    15. Cantu syndrome is caused by mutations in ABCC9 PMID: 22608503
    16. mammalian oocytes express K(ATP) channels. Real-time PCR revealed that mRNA for Kir6.1, Kir6.2, SUR2A and SUR2B, were present in human oocytes of different stages. PMID: 20847183
    17. sequence variants in ABCC9 is unlikely to contribute to variation in postural change in systolic blood pressure PMID: 19952277
    18. These findings suggest that abnormal localization of the SUR2A K(+) channel protein leads to reduced K(ATP) channel activity in familial hypokalemic periodic paralysis. PMID: 19962959
    19. Assembly limits the pharmacological complexity of ATP-sensitive potassium channels PMID: 11825905
    20. down-regulation of this channel may facilitate myometrial function during late pregnancy PMID: 12356945
    21. In corporal smooth muscle is composed of Kir6.1-Kir6.2 construct expressed with SUR2B.K(ATP) channel in corporal smooth muscle cells is composed of heteromultimers of Kir6.1 and Kir6.2 with the ratio of 3 : 1 or 4 : 0 and SUR2B. PMID: 12934053
    22. role of mutation in human dilated cardiomyopathy and effect on KATP channel gating PMID: 15034580
    23. Syn-1A binds both NBFs of SUR1 and SUR2A but appears to exhibit distinct interactions with NBF2 of these SUR proteins in modulating the KATP channels in islet beta cells and cardiac myocytes PMID: 15339904
    24. newly discovered 734Ile allele in ABCC9 might influence susceptibility to precocious myocardial infarct in our population PMID: 16563363
    25. Syntaxin-1A actions on sulfonylurea receptor 2A blocks acidic pH-induced cardiac K(ATP) channel activation PMID: 16672225
    26. Results describe a new function of the Kir6.1-SUR2A complex, namely the regulation of paracellular permeability through tight junctions. PMID: 16820413
    27. review the structure and function of ABC proteins and discuss SUR, its regulation of the K(ATP) channel, and its role in cardiovascular disease. PMID: 18239147
    28. caveolin-dependent internalization is involved in PKC-epsilon-mediated inhibition of vascular K(ATP) channels (Kir6.1 and SUR2B) by phorbol 12-myristate 13-acetate or angiotensin II PMID: 18663158
    29. Kir6.1/SUR2B is the major functional K(ATP) channel complex in the pig MMA and MCA, and mRNA expression studies suggest that the human MMA shares this K(ATP) channel subunit profile PMID: 18996111
    30. caveolin-3 negatively regulates Kir6.2/SUR2A channel function. PMID: 19481058

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  • 相關疾病：
    Cardiomyopathy, dilated 1O (CMD1O); Atrial fibrillation, familial, 12 (ATFB12); Hypertrichotic osteochondrodysplasia (HTOCD)
  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
  • 數據庫鏈接：

    HGNC: 60

    OMIM: 239850

    KEGG: hsa:10060

    STRING: 9606.ENSP00000261200

    UniGene: Hs.732701



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