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  4. Recombinant Human AT-rich interactive domain-containing protein 5B (ARID5B), partial

Recombinant Human AT-rich interactive domain-containing protein 5B (ARID5B), partial

  • 中文名稱：
    Recombinant Human AT-rich interactive domain-containing protein 5B(ARID5B) ,partial
  • 貨號：
    CSB-YP623937HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human AT-rich interactive domain-containing protein 5B(ARID5B) ,partial
  • 貨號：
    CSB-EP623937HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human AT-rich interactive domain-containing protein 5B(ARID5B) ,partial
  • 貨號：
    CSB-EP623937HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human AT-rich interactive domain-containing protein 5B(ARID5B) ,partial
  • 貨號：
    CSB-BP623937HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human AT-rich interactive domain-containing protein 5B(ARID5B) ,partial
  • 貨號：
    CSB-MP623937HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ARI5B_HUMAN; ARID domain-containing protein 5B; Arid5b; AT rich interactive domain 5B (MRF1 like); AT-rich interactive domain-containing protein 5B; DESRT; FLJ21150; FLJ41888; Modulator recognition factor 2 (MRF2); Modulator recognition factor 2; MRF-2; Mrf1-like; MRF1-like protein; MRF2; OTTHUMP00000019668; RP11 341A19.1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer.
  • 基因功能參考文獻：
    1. Differential methylation and expression of ARID5B to be associated with human atherosclerosis. PMID: 28855511
    2. The present results identified MRF2/ARID5B as a potential susceptibility gene for new-onset T2DM in a Northern Chinese population, while the rs7087507 SNP was associated with HDL-C levels. Further larger studies are required to validate these findings. PMID: 28469100
    3. We systematically screened 6 potentially functional SNPs in ARID5B and IKZF1 genes. PMID: 29292192
    4. ARID5B reinforces the oncogenic transcriptional program by positively regulating the TAL1-induced regulatory circuit and MYC in T-ALL, thereby contributing to T-cell leukemogenesis. PMID: 29326336
    5. Results identified a novel hotspot in the terminal exon of ARID5B.The ARID5B indel mutations were seen in both mismatch repair (MMR)-deficient and MMR-normal tumors, suggesting biologic selection in endometrial neoplasm. PMID: 27346418
    6. Our results confirmed the role of ARID5B in childhood ALL susceptibility among Hispanics; however, our assessment did not reveal any strong novel inherited genetic risks for acute lymphoblastic leukemia among this ethnic group. PMID: 28817678
    7. Associations between ALL and rs10821936 and rs7089424 ARID5B SNPs were found PMID: 28476190
    8. ARID5B variants are associated with acute lymphoblastic leukemia in Yemeni children with several gender biases of ARID5B single nucleotide polymorphisms reported. PMID: 28381164
    9. variants within IKZF1, ARID5B, and CEBPE were associated with pediatric ALL risks. PMID: 27184773
    10. Genotypic and allelic frequencies differed significantly between cases and controls at IKZF1-rs4132601 (p=0.039, p=0.015) and ARID5B-rs10821936 (p=0.028, p=0.026). PMID: 27644650
    11. Single nucleotide polymorphisms rs10994982 and rs7089424 in ARID5B gene are associated with increased risk of childhood acute lymphoblastic leukemia. PMID: 25124600
    12. This study showed that rs4948496 in ARID5B is associated with several subphenotypes of systemic lupus erythematosus and this gene may cause the complicacy of clinical features. PMID: 25808444
    13. Non-coding variant rs10821936 in ARID5B was strongly associated with childhood B-cell acute lymphoblastic leukemia. No coding variants were associated with B-ALL susceptibility. PMID: 26104880
    14. variants within IKZF1, ARID5B, and CEBPE were associated with increased acute lymphoblastic leukemia (ALL) risk, and the effects for ARID5B and CEBPE were most prominent in high-hyperdiploid ALL subtype in the California Hispanic population PMID: 25761407
    15. Data indicate no significant associations of transcription factors rs4132601 (IKZF1), rs7089424 (ARID5B) and rs2239633 (CEBPE) with risk of pediatric non-Hodgkin lymphoma (NHL). PMID: 25005032
    16. Interactions between rs10740055 in ARID5B or rs4132601 in IKZF1 and each of the suspected non-genetic factors were tested. PMID: 25806972
    17. These results evidence that interaction of genetic variants in ARID5B and IKZF1 and environmental exposures may further alter risk of childhood acute lymphoblastic leukemia. PMID: 25310577
    18. ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia. PMID: 24564228
    19. Our findings confirm the association of novel genetic variations in folate-related and ARID5B genes with the serum MTX levels and acute toxicity. PMID: 24712521
    20. We found that rs7073837 in ARID5B correlated with a risk for childhood B lineage ALL. PMID: 24200646
    21. study found that previously identified childhood acute lymphoblastic leukemia susceptibility loci in ARID5B and CEBPE show consistent risk effects across both Hispanic and non-Hispanic White populations, providing compelling supportive evidence for susceptibility at these loci PMID: 23836053
    22. Germline variants in IKZF1, ARID5B, and CEBPE as risk factors for adult-onset acute lymphoblastic leukemia: an analysis from the GMALL study group. PMID: 24497567
    23. In an epigenome-wide methylation Norwegian Mother-Baby cohort study 2 ARID5B CpGs were identified in cord blood DNA as having an inverse association with birth weight (higher methylation fraction associated with lower birth weight). PMID: 24561991
    24. ARID5B genetic polymorphism was associated with the increased risk of ALL. PMID: 23975371
    25. variants of rs2893880, rs10740055, rs7087507 and rs10761600 on the ARID5B gene were associated with susceptibility to type 2 diabetes PMID: 22971728
    26. The intron 3 of ARID5B gene was found to be strongly associated with B-ALL risk in the Spanish population examined. PMID: 24013273
    27. Data indicate associations between childhood acute lymphoblastic leukemia (ALL) and ARID5B and IKZF1 SNPs. PMID: 23692655
    28. ARID5B single nucleotide polymorphism rs10821936 is associated with an increased risk of childhood acute lymphoblastic leukemia in Chinese population. PMID: 23608171
    29. ARID5B polymorphisms are associated with childhood acute myeloblastic leukemia. PMID: 22922568
    30. Although germ-line SNPs in ARID5B, CEBPE, IKZF1 and CDKN2A are associated with the incidence of ALL in children, authors found no significant association between adult ALL cases and controls. PMID: 23016962
    31. Association of the autoimmune thyroid disease phenotype (both Graves disease and Hashimoto's thyroiditis) with SNP rs6479778 located within the ARID5B gene. PMID: 23118423
    32. confirmed the association of 5 SNPs [rs7073837 (P=4.2 x 10(-4)), rs10994982 (P=3.8 x 10(-4)), rs10740055 (P=1.6 x 10(-5)), rs10821936 (P=1.7 x 10(-7)) and rs7089424 (P=3.6 x 10(-7))] in the ARID5B gene with childhood acute lymphoblastic leukemia PMID: 20460642
    33. ARID5B polymorphisms are important determinants of childhood ALL susceptibility and treatment outcome, and they contribute to racial disparities in this disease. PMID: 22291082
    34. Single nucleotide polymorphism in ARID5B gene is associated with childhood acute lymphoblastic leukemia. PMID: 21889209
    35. ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence. PMID: 20054350
    36. The results implicate possible disease relevance of the polymorphisms in the Mrf-2 gene with susceptibility to CAD PMID: 18612189
    37. The ARID5B single nucleotide polymorphisms distinguished B-hyperdiploid ALL from other subtypes in an independent validation cohort and were associated with methotrexate accumulation and gene expression patterns in leukemic lymphoblasts. PMID: 19684603
    38. NMR spectroscopy studies of Mrf-2 in complex with DNA suggest that two flexible interhelical loops, the flexible C-terminal tail, and one alpha-helix are involved in DNA recognition, indicating the importance of protein dynamics in DNA binding. PMID: 11478881

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  • 相關疾病：
    Leukemia, acute lymphoblastic (ALL)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    ARID5B family
  • 組織特異性：
    Widely expressed, including in liver (at protein level).
  • 數據庫鏈接：

    HGNC: 17362

    OMIM: 608538

    KEGG: hsa:84159

    STRING: 9606.ENSP00000279873

    UniGene: Hs.535297



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