在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human AP-2 complex subunit alpha-2 (AP2A2), partial

  • 中文名稱:
    Recombinant Human AP-2 complex subunit alpha-2(AP2A2) ,partial
  • 貨號(hào):
    CSB-YP001870HU
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human AP-2 complex subunit alpha-2(AP2A2) ,partial
  • 貨號(hào):
    CSB-EP001870HU
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human AP-2 complex subunit alpha-2(AP2A2) ,partial
  • 貨號(hào):
    CSB-EP001870HU-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human AP-2 complex subunit alpha-2(AP2A2) ,partial
  • 貨號(hào):
    CSB-BP001870HU
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human AP-2 complex subunit alpha-2(AP2A2) ,partial
  • 貨號(hào):
    CSB-MP001870HU
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    100 kDa coated vesicle protein C; Adaptor protein complex AP-2 subunit alpha-2; Adaptor-related protein complex 2 subunit alpha-2; Alpha-adaptin C; Alpha2-adaptin; AP-2 complex subunit alpha-2; Ap2a2; AP2A2_HUMAN; Clathrin assembly protein complex 2 alpha-C large chain; HIP-9; Huntingtin yeast partner J; Huntingtin-interacting protein 9; Huntingtin-interacting protein J; Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

相關(guān)產(chǎn)品

靶點(diǎn)詳情

  • 功能:
    Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
  • 基因功能參考文獻(xiàn):
    1. AP2 has evolved as a key regulatory node to coordinate clarhtin-coated pit formation and cargo sorting and ensure high spatial and temporal regulation of cathrin-mediated endocytosis. PMID: 28003333
    2. the AP-2 complex is not associated with the endocytosed plasma membrane-associated clathrin PMID: 14530274
    3. The mutation of lysine-297 and arginine-340 on the alpha-adaptin specifically inhibits the ability of Nef to bind AP-2 and downregulate CD4. PMID: 19129443
    4. Clathrin-dependent endocytosis of human CD317 from the cell surface lipid rafts is mediated by direct interaction with alpha-adaptin. PMID: 19359243
  • 亞細(xì)胞定位:
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族:
    Adaptor complexes large subunit family
  • 組織特異性:
    Expressed in the brain (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 562

    OMIM: 607242

    KEGG: hsa:161

    STRING: 9606.ENSP00000413234

    UniGene: Hs.19121



主站蜘蛛池模板: 毛片无码免费无码播放| 性欧美大胆免费播放| 婷婷四房综合激情五月| 国产后进白嫩翘臀在线播放| 日韩在线一区二区三区免费视频| 久激情内射婷内射蜜桃人妖| 国产按头口爆吞精在线视频| 色老99久久精品偷偷鲁| 麻豆果冻传媒2021精品传媒一区 | 亚洲娇小与黑人巨大交| 无码精品人妻一区二区三区影院| 任我撸在线视频| 亚洲乱码无码永久不卡在线| 亚洲亚洲人成无码网www| 天堂资源在线www在线观看| 伊人久久综合色| 国产一区二区| 中文天堂在线www最新版官网| 国产成在线观看免费视频| 日本亚洲欧美综合在线| 亚洲v欧美v国产v在线观看| 无码一区二区三区在线观看| 99热门精品一区二区三区无码| 印度妓女野外xxww| 色yeye香蕉凹凸视频在线观看| 亚洲色欲色欲www| 久久日本三级韩国三级| 亚洲女人色综合小说| 日本污ww视频网站| 日韩欧美人妻一区二区三区| 欧美人与动牲交a欧美| 欧美熟妇性xxxx交潮喷| 精品偷拍一区二区三区在线看| 亚洲精品无码久久久久久| 国产超薄肉色丝袜视频| 亚洲精品av网站在线观看| 无码里番纯肉h在线网站| 人人妻在人人| 久久香蕉国产线看观看手机| 50岁熟妇的呻吟声对白| 99精品国产成人一区二区|