Recombinant Human AP-1 complex subunit sigma-2 (AP1S2)

中文名稱：

Recombinant Human AP-1 complex subunit sigma-2(AP1S2)
貨號：

CSB-YP001867HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human AP-1 complex subunit sigma-2(AP1S2)
貨號：

CSB-EP001867HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human AP-1 complex subunit sigma-2(AP1S2)
貨號：

CSB-EP001867HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human AP-1 complex subunit sigma-2(AP1S2)
貨號：

CSB-BP001867HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human AP-1 complex subunit sigma-2(AP1S2)
貨號：

CSB-MP001867HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

AP1S2
Uniprot No.：

P56377
別名：

Adapter related protein complex 1 sigma 1B subunit; Adapter-related protein complex 1 sigma-1B subunit; Adaptor protein complex AP 1 sigma 1B subunit; Adaptor protein complex AP-1 sigma-1B subunit; Adaptor related protein complex 1 sigma 2 subunit; AP 1 complex subunit sigma 2; AP-1 complex subunit sigma-2; ap1s2; AP1S2_HUMAN; Clathrin adaptor complex AP1 sigma 1B subunit; Clathrin assembly protein complex 1 sigma 1B small chain; Clathrin assembly protein complex 1 sigma-1B small chain; Clathrin associated assembly adaptor protein small 1 like; DC22; Golgi adaptor HA1 AP1 adaptin sigma 1B subunit; Golgi adaptor HA1/AP1 adaptin sigma-1B subunit; mental retardation X linked 59; MGC:1902; MRX59; Sigma 1B subunit of AP 1 clathrin; Sigma 1B subunit of AP-1 clathrin; Sigma adaptin 1B; Sigma-adaptin 1B; Sigma1B adaptin; SIGMA1B; Sigma1B-adaptin
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區(qū)域：

1-157
氨基酸序列

MQFMLLFSRQ GKLRLQKWYV PLSDKEKKKI TRELVQTVLA RKPKMCSFLE WRDLKIVYKR YASLYFCCAI EDQDNELITL EIIHRYVELL DKYFGSVCEL DIIFNFEKAY FILDEFLLGG EVQETSKKNV LKAIEQADLL QEEAETPRSV LEEIGLT
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
基因功能參考文獻：
1. sigma1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue. PMID: 24928897
2. The AP1S2 c.426+1 G>T mutation segregates with the disease in the Pettigrew syndrome family. PMID: 23756445
3. A mutation in the 3d intron causes skipping of exon 3 yielding a protein with 3 new AAs terminating at codon 64. A new nonsense mutation p.Gln66X was found in exon 3. Without AP1S2, defective membrane protein trafficking alters brain neural cell fate. PMID: 17617514
4. absence of an AP-1 defect in peripheral tissues is due to functional redundancy among AP-1 subunits PMID: 18428203
相關(guān)疾病：

Pettigrew syndrome (PGS)
亞細(xì)胞定位：

Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
蛋白家族：

Adaptor complexes small subunit family
組織特異性：

Widely expressed.
數(shù)據(jù)庫鏈接：

HGNC: 560

OMIM: 300629

KEGG: hsa:8905

STRING: 9606.ENSP00000328789

UniGene: Hs.121592