Recombinant Human ALS2 C-terminal-like protein (ALS2CL), partial

中文名稱：

Recombinant Human ALS2 C-terminal-like protein(ALS2CL) ,partial
貨號：

CSB-YP717181HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human ALS2 C-terminal-like protein(ALS2CL) ,partial
貨號：

CSB-EP717181HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human ALS2 C-terminal-like protein(ALS2CL) ,partial
貨號：

CSB-EP717181HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human ALS2 C-terminal-like protein(ALS2CL) ,partial
貨號：

CSB-BP717181HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human ALS2 C-terminal-like protein(ALS2CL) ,partial
貨號：

CSB-MP717181HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

ALS2CL
Uniprot No.：

Q60I27
別名：

AL2CL_HUMAN; ALS2 C-terminal like; ALS2 C-terminal-like protein; Als2cl; DKFZp686I0110; DKFZp686P238; FLJ36525; MGC129698; RN49018
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.
基因功能參考文獻：
1. This supports the notion that de novo mutations in ALS2CL are extremely rare in schizophrenia PMID: 23425335
2. Data provide further support that ALS2CL, EPHA3, and CMYA1 are bona-fide tumor-suppressor genes and contribute to the tumorigenesis of HNSCC. PMID: 20657180
3. These results suggest that amyotrophic lateral sclerosis 2 C-terminal like (ALS2CL), a novel ALS2 homologue, modulates Rab5-mediated endosome dynamics in HeLa cells. PMID: 15388334
4. ALS2CL is a novel ALS2-interacting protein implicated in ALS2-mediated endosome dynamics. PMID: 17239822
亞細胞定位：

Cytoplasm. Note=Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells.
組織特異性：

Expressed in heart and kidney.
數(shù)據(jù)庫鏈接：

HGNC: 20605

OMIM: 612402

KEGG: hsa:259173

STRING: 9606.ENSP00000313670

UniGene: Hs.517937