在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human ADP/ATP translocase 3 (SLC25A6), partial

  • 中文名稱:
    人SLC25A6重組蛋白
  • 貨號:
    CSB-YP021520HU1
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人SLC25A6重組蛋白
  • 貨號:
    CSB-EP021520HU1-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人SLC25A6重組蛋白
  • 貨號:
    CSB-BP021520HU1
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人SLC25A6重組蛋白
  • 貨號:
    CSB-MP021520HU1
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    SLC25A6; AAC3; ANT3; CDABP0051; ADP/ATP translocase 3; ADP,ATP carrier protein 3; ADP,ATP carrier protein, isoform T2; ANT 2; Adenine nucleotide translocator 3; ANT 3; Solute carrier family 25 member 6
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it.
  • 基因功能參考文獻:
    1. Human ANT3 expression is directly downregulated by overexpression of hcmv-miR-UL36-5p. PMID: 26212361
    2. The dynamics of the molecular interactions between the C-terminal region of PB1-F2 protein and VDAC1 and ANT3 were expounded by employing an in silico approach. PMID: 19669810
    3. Of three ANT isoforms expressed in yeast, ANC3 is the most efficient to restore yeast growth on a nonfermentable carbon source of a yeast mutant strain lacking its three endogenous ANC. PMID: 12450408
    4. Results demonstrate that induction of adenine nucleotide translocase 3 by interleukin-4 and interferon-gamma proceeds via pathways involving STAT6 and STAT1, respectively. PMID: 14746803
    5. ANT3 overexpression induces apoptosis in cultured cells. PMID: 15063741
    6. ANT3 has a potential role in T-helper cell survival and immune cell homeostasis. PMID: 16930576
    7. involvement of ANT in cell death is cell type- and stimulus-dependent PMID: 17855512
    8. These data suggest that the down-regulation of ANT3 levels upon stimulation with CPT may be involved in the molecular mechanism underlying acquired resistance to camptothecin. PMID: 19111545

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Mitochondrial carrier (TC 2.A.29) family
  • 組織特異性:
    Expressed in erythrocytes (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 10992

    OMIM: 300151

    KEGG: hsa:293

    STRING: 9606.ENSP00000370808

    UniGene: Hs.350927



主站蜘蛛池模板: 成人性生交大片免费看r老牛网站| 8888四色奇米在线观看| 2019nv天堂香蕉在线观看| 国产成人麻豆精品午夜福利在线| 亚洲a综合一区二区三区| 高清免费精品国自产拍| 久久人妻av一区二区软件| 天堂在/线资源中文在线| 好男人www社区视频在线资源| 嫩草研究院久久久精品| 国产国产乱老熟女视频网站97| 色综合久久88色综合天天| 午夜福利不卡在线视频| 中文字幕精品av乱码在线 | 无码人妻熟妇av又粗又大| 国产精品沙发系列| 少妇被黑人4p到惨叫欧美人| 华人少妇被黑人粗大的猛烈进| 国产情侣真实露脸在线| 成 人 亚洲 综合天堂| 97精品国产一区二区三区四区| 日本熟妇浓毛| 夜夜躁狠狠躁日日躁孕妇| 亚洲精品久久66国产高清| 国产成人av一区二区在线观看| 热re99久久精品国产66热| 国产人妻大战黑人第1集| 在线天堂中文官网| 曰曰摸夜夜添夜夜添高潮出水| 亚洲卡1卡2卡新区网站| 国产av成人无码精品网站| 精品无码久久久久久久久久| 国产69精品久久久久人妻刘玥| 色欲av久久综合人妻无码| 亚洲精品久久久口爆吞精| 中文字幕乱码中文乱码51精品| 巨大乳做爰视频在线看| 成人国产精品一区二区免费看| 国产亚洲精品a在线无码| 国产成人手机高清在线观看网站| 中国猛少妇色xxxxx|