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Recombinant Human A-kinase anchor protein 12 (AKAP12 AKAP250)

  • 中文名稱:
  • 貨號(hào):
    CSB-YP896230HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
  • 貨號(hào):
    CSB-EP896230HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
  • 貨號(hào):
    CSB-EP896230HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
  • 貨號(hào):
    CSB-BP896230HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
  • 貨號(hào):
    CSB-MP896230HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    AKA12
  • Uniprot No.:
  • 別名:
    A-kinase anchor protein 12; AKAP-12; A-kinase anchor protein 250 kDa; AKAP 250; Gravin; Myasthenia gravis autoantigen; AKAP12 AKAP250
  • 種屬:
    Homo sapiens (Human)
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
  • 基因功能參考文獻(xiàn):
    1. Low AKAP12 expression is associated with high-grade meningiomas. PMID: 29391485
    2. There is a positive association between the expression of AKAP12 and Semaphorin 3F in prostate cancer, suggesting that the activation of Semaphorin 3F by AKAP12 may be involved in prostate cancer progression and metastasis. PMID: 28698137
    3. A critical role for AKAP12 as an UV-inducible scaffold for PKA-mediated ATR phosphorylation. PMID: 27683220
    4. the AKAP12a promoter shows high DNA methylation levels in juvenile myelomonocytic leukemia, which go along with reduced AKAP12a mRNA expression levels PMID: 26891149
    5. MiR-103 regulates hepatocellular carcinoma growth by targeting AKAP12 PMID: 26646106
    6. results suggest that the association between the 6q25.1 locus and breast cancer risk may be mediated through single nucleotide polymorphisms that regulate expressions of the AKAP12 gene. PMID: 26645718
    7. The authors propose that Gravin-mediated recruitment of Aurora A and Plk1 to the mother (oldest) spindle pole contributes to the fidelity of symmetric cell division. PMID: 26406118
    8. The SSeCKS, a major Lipopolysaccharide (LPS) response protein, has been involved in regulating astrocyte activation via production of proinflammatory factor in CNS inflammation. PMID: 26428665
    9. Elevated expression of AKAP12 is characteristic of paclitaxel-resistant high-grade serous ovarian cancer cells, and a prognostic and predictive marker for poor overall survival in SOC patients. PMID: 25748058
    10. The enrichment of activated Cdc42 in SSeCKS-null leading edge filopodia correlated with recruitment of the Cdc42-specific guanine nucleotide exchange factor, Frabin. PMID: 25356636
    11. AKAP12 scaffolding protein mediates meningeal reconstruction after central nervous system injury PMID: 25229625
    12. PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation. PMID: 25188285
    13. This study showed that AKAP12,CAMK2D and a molecular pathway(cyclic amp)association to outcome of depressive during citalopram treatment. PMID: 24986638
    14. AKAP12 variant 2 hypoxic induction shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells PMID: 25792458
    15. AKAP12 expression was positive in 82.2% of tumors in a cohort with colorectal adenocarcinoma. AKAP12 expression was unrelated to p53 or Bcl-2 expression. PMID: 24870731
    16. Receptor-mediated Ca2+ and PKC signaling triggers the loss of cortical PKA compartmentalization through the redistribution of gravin. PMID: 23838009
    17. High AKAP12 expression is associated with colorectal cancer. PMID: 24065476
    18. AKAP12 is differentially expressed in human astrocytomas showing high expression in pilocytic but low expression in diffuse astrocytomas of all WHO-grades. further, epigenetic mechanisms are involved in silencing AKAP12 in diffuse astrocytomas PMID: 24042196
    19. Gravin gene expression is decreased in acute myeloid leukemia and correlates with poor prognosis. PMID: 23543478
    20. Data suggest a model in which SSeCKS suppresses oncogenic motility by sequestering Src to caveolin-rich lipid rafts, thereby disengaging Src from FAK-associated adhesion and signaling complexes. PMID: 22710722
    21. demonstrated for the first time that AKAP12 tumor/angiogenesis suppressor gene is an epigenetic target of HDAC7 PMID: 22584896
    22. It defines a role for Gravin as a temporal organizer of phosphorylation-dependent protein-protein interactions during mitosis. PMID: 23063527
    23. The results demonstrate that AKAP12 may play an important role in tumor growth suppression and the survival of human colorectal cancer. PMID: 21918680
    24. PKC-mediated remodeling of the actin cytoskeleton is likely regulated by the ability of SSeCKS to control PKC signaling and activity through a direct scaffolding function PMID: 21903576
    25. AKAP12 is involved in the regulation of endothelial cell migration through the inhibitory regulation of MMP-9 expression in tumor cells. PMID: 21461577
    26. AKAP12 promoter methylation is a frequent event in human prostate cancer. PMID: 21310466
    27. SERPINB5 and AKAP12 may have a role in increased metastasis in pancreatic ductal adenocarcinoma PMID: 20939879
    28. Data show that AKAP12 methylation represents a potential molecular biomarker for predicting the malignancy of colorectal cancer. PMID: 20364105
    29. AKAP12alpha promoter methylation is associated with lung cancer. PMID: 21115911
    30. In addition to genetic alterations, epigenetic mechanisms are responsible for the reduction of the tumor suppressor gene AKAP12 in human hepatocarcinogenesis. PMID: 20979053
    31. Findings suggest that SSeCKS suppresses metastatic motility by disengaging activated Src and then inhibiting the PKC-Raf/MEK/ERK pathways controlling matrix metalloproteinase-2 expression and podosome formation. PMID: 20018890
    32. gravin provides a dynamic platform for the localization for kinases during neuronal development PMID: 12857743
    33. AKAP250 acts as a scaffold that binds protein kinase A (PKA), protein kinase C and protein phosphatases, associating reversibly with the beta(2)-adrenergic receptor. PMID: 14657015
    34. AKAP12A may function as an important negative regulator of the survival pathway in human gastric cancer. PMID: 15258566
    35. AKAP12alpha belongs to a novel class of atypical SRF-dependent target genes PMID: 15590635
    36. AKAP12 localization is regulated by a hierarchy of targeting domains and the localization of AKAP12-assembled signaling complexes may be dynamically regulated PMID: 15923193
    37. Results suggest that gravin maintains a signaling complex that includes protein kinase A and phosphodiesterase 4D. PMID: 16642035
    38. Membrane binding of gravin, and thus function, can be reversed by calcium/calmodulin, which binds to the membrane and causes translocation of gravin from membrane to cytoplasm. PMID: 16762919
    39. We conclude that LPA-dependent increased level of cAMP in senescent human diploid fibroblasts is associated with increases in Gravin levels resulting in its increased binding with and activation of calcium-dependent PKC alpha/beta and AC4/6. PMID: 17081159
    40. The Src-binding peptide-(1-51) of gravin behaves as a dominant-negative for AKAP gravin regulation of beta2-adrenergic receptor resensitization/recycling PMID: 17200117
    41. Results suggest that AKAP12 may play an important role in tumor growth suppression by inducing apoptosis with the regulation of multiple molecules in the cell cycle progression. PMID: 17442483
    42. AKAP12 may induce BRB formation through antiangiogenesis and barriergenesis in developing human eye and defects in this mechanism can lead to loss of tight junction proteins and contribute to development of retinal pathologies such as retinoblastoma. PMID: 17442832
    43. The Gravin expression was found to be decreased in samples of acute leukaemia and was associated with an inferior overall survival. PMID: 17577780
    44. Hypermethylation of the AKAP12 promoter is associated esophageal carcinoma. PMID: 18199717
    45. AKAP12 in astrocytes induces barrier functions in human endothelial cells through protein kinase Czeta. PMID: 18397319
    46. These findings implicate AKAP12 in the regulation of cytokinesis progression, and suggest a novel role for AKAP12 tumor suppressor. PMID: 18554502
    47. Results suggest that AKAP12A may activate SREBP-2 by increasing cholesterol efflux, and is a novel regulator of cellular cholesterol metabolism. PMID: 18579430
    48. AKAP12 docks to the beta2-adrenergic receptor in response to agonist stimulation, later internalizes with agonist-induced receptors, and finally dissociates from the recycled, cell membrane-bound receptor. PMID: 18950703
    49. Data show that PKC activation resulted in redistribution of gravin and PKA constructs to the same subcellular site, and suggest that this response to PKC activity may mediate PKC dependent control of PKA activity. PMID: 19210988
    50. Data revealed that six polymorphisms of F10, PITRM1, PCSK2, JPH3, MYO7B, and AKAP12 were related (P<0.05) to the prevalence of chronic kidney disease. PMID: 19724895

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  • 亞細(xì)胞定位:
    Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Membrane; Lipid-anchor. Note=May be part of the cortical cytoskeleton.
  • 組織特異性:
    Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 370

    OMIM: 604698

    KEGG: hsa:9590

    STRING: 9606.ENSP00000253332

    UniGene: Hs.371240



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