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  4. Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12), partial

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12), partial

  • 中文名稱：
    Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 12(ADAMTS12) ,partial
  • 貨號：
    CSB-YP001300HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 12(ADAMTS12) ,partial
  • 貨號：
    CSB-EP001300HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 12(ADAMTS12) ,partial
  • 貨號：
    CSB-EP001300HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 12(ADAMTS12) ,partial
  • 貨號：
    CSB-BP001300HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 12(ADAMTS12) ,partial
  • 貨號：
    CSB-MP001300HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ADAMTS12
  • Uniprot No.：
  • 別名：
    ADAMTS12; UNQ1918/PRO4389A disintegrin and metalloproteinase with thrombospondin motifs 12; ADAM-TS 12; ADAM-TS12; ADAMTS-12; EC 3.4.24.-
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties.
  • 基因功能參考文獻：
    1. ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group. PMID: 29135310
    2. ADAMTS12 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    3. Decreased levels of ADAMTS-12 were found to be associated with intrahepatic cholestasis of pregnancy. PMID: 26363034
    4. ADAMTS-12 is a multifaced metalloproteinase in arthritis and inflammation [review] PMID: 24876675
    5. ADAMTS-12 is implicated in the inflammatory response by modulating normal neutrophil apoptosis. PMID: 23019333
    6. Our results suggest that ADAMTS12 may be a susceptibility gene for RA development. PMID: 22505177
    7. statistically significant increase in mRNA expression of ADAMTS-7 and ADAMTS-12 was observed in the endplate cells in degenerative discs compared with nondegenerative discs PMID: 22247065
    8. The data supported the hypothesis that genetic variations in ADAMTS12 influence the risk of schizophrenia. PMID: 22322903
    9. expression of ADAMTS12 in colorectal cancer stroma plays an important role in inhibiting tumor development PMID: 21559743
    10. This study identifies a novel biological role for ADAMTS-12, and highlights the importance and complexity of its non-proteolytic domain(s) pertaining to its function. PMID: 21494557
    11. ADAMTS-12 is a new COMP-interacting and -degrading enzyme and thus may play an important role in the COMP degradation in the initiation and progression of arthritis PMID: 16611630
    12. data suggest that ADAMTS12 confers tumour-protective functions upon cells that produce this proteolytic enzyme PMID: 17895370
    13. ADAMTS-7 and ADAMTS-12 are newly identified enzymes responsible for cartilage oligomeric matrix protein degradation in arthritis. PMID: 19098927
    14. Results demonstrate that ADAMTS-12, a downstream molecule of PTHrP signaling, is a novel regulator of chondrogenesis. PMID: 19151918
    15. ADAMTS-12 is a novel anti-tumor protease that can reduce the proliferative properties of tumor cells. PMID: 19638407

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  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 組織特異性：
    Expressed in skeletal muscle and fat.
  • 數據庫鏈接：

    HGNC: 14605

    OMIM: 606184

    KEGG: hsa:81792

    STRING: 9606.ENSP00000422554

    UniGene: Hs.12680



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