在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human 5-hydroxytryptamine receptor 6 (HTR6), partial

Recombinant Human 5-hydroxytryptamine receptor 6 (HTR6), partial

  • 中文名稱：
    人HTR6重組蛋白
  • 貨號：
    CSB-YP010898HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HTR6重組蛋白
  • 貨號：
    CSB-EP010898HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HTR6重組蛋白
  • 貨號：
    CSB-EP010898HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HTR6重組蛋白
  • 貨號：
    CSB-BP010898HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HTR6重組蛋白
  • 貨號：
    CSB-MP010898HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    HTR6; 5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity. Is an activator of TOR signaling.
  • 基因功能參考文獻：
    1. Serotonin 6 receptor has a role in Alzheimer's disease and depression PMID: 26449188
    2. that HTR6 plays an important role in modulating seizure activity and that the blockade of the 5-HT6 receptor/mTOR pathway could be a potential therapeutic target for epilepsy treatment PMID: 25034463
    3. Studies indicate that serotonin 5-HT6 receptor (5-HT6R) has been proposed as a promising drug target for cognition enhancement in Alzheimer's disease (AD). PMID: 24850589
    4. [review] Controlling the activity of 5-HTR6 receptors seems to provide benefits by alleviating cognitive impairments. PMID: 23844689
    5. Data indicate that hydrogen-bond formation of a methoxy or hydroxy group is not important for binding at the 5-HT6 receptor. PMID: 23542166
    6. The human cloned 5-HT6 receptor is stably transfected in HeLa cells. PMID: 15482912
    7. When expressed in pyramidal neuron progenitors, serotonin receptor 5-HT6 transgene decreases the migration speed of cortical pyramidal neurons, thereby affecting a fundamental step in the assembly of neural circuits. PMID: 22833193
    8. These observations suggest that recruitment of mTOR by prefrontal 5-HT(6) receptors contributes to the perturbed cognition in schizophrenia, offering new vistas for its therapeutic control. PMID: 23027611
    9. There was a statistically significant difference in semantic memory scores among the three genotype groups of T267C in 5-HT6. PMID: 21728060
    10. present findings showed the presence of a higher density of 5-HT(6) receptors, as labeled by [(125)I]SB-258585, in striatum than in hippocampus and prefrontal cortex, and specifically within the neuronal body PMID: 22278721
    11. results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia. PMID: 22745941
    12. [review] Since discovery of the 5-HT6 receptor and development of its small-molecule ligands, neurochemical and localization studies have clearly demonstrated its central role in modulating GABAergic neurotransmission across brain structures and networks. PMID: 21329782
    13. detected association between 2 markers (rs6693503 and rs1805054) and three markers (rs6693503, rs1805054 and rs4912138) in HTR6 and METH-induced psychosis respectively. HTR6 may play important role in pathophysiology of METH-induced psychosis in Japanese PMID: 20705401
    14. Common variants in the gene for HT6R do not contribute to obesity. PMID: 21273698
    15. we found no association involving HTR6 polymorphism and mood disorder in the Japanese population PMID: 20394784
    16. Data show that analogues of 5-cyclic amine-3-arylsulfonylindazoles have been identified as high-affinity 5-HT(6) receptor ligands. PMID: 20170099
    17. Jab1 provides a novel signal transduction pathway for 5-HT(6)R and may play an important role in 5-HT(6)R-mediated behavior changes in the brain PMID: 20093369
    18. SNP might have a role in the etiology of suicide in male subjects in the Portuguese population. PMID: 19782122
    19. 5-HT6 receptor gene polymorphism C267T is associated with Parkinson's disease. PMID: 11889255
    20. Association of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease. apolipoprotein E epsilon 4 status. the 267C allele of the 5-HT(6) receptor gene may not be a genetic risk factor for AD. PMID: 12023056
    21. significant relationship between 5-HT(6) receptor gene polymorphism (C267T) and self-transcendence PMID: 14698468
    22. These data do not support the idea that the 5-HT(6) receptor gene plays a major role in the etiopathogenesis of schizophrenia. PMID: 15048641
    23. The serotonin type 6 (5-HT(6)) receptor is a G-protein coupled receptor (GPCR) coupled to a stimulatory G-protein (G(S)). PMID: 15737640
    24. In aging control patients, the 5-HT6 receptor was expressed by pyramidal cells and some stellate cells,in layers II-V, and layer I, where a distinct label was observed in neurons and surrounding fibers.In AD patients was significantly decreased by 40%. PMID: 16640790

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Expressed in several human brain regions, most prominently in the caudate nucleus.
  • 數據庫鏈接：

    HGNC: 5301

    OMIM: 601109

    KEGG: hsa:3362

    STRING: 9606.ENSP00000289753

    UniGene: Hs.22180



主站蜘蛛池模板： 五月天激情电影| 夜夜添无码一区二区三区| 久久99热人妻偷产国产| 国产成人久久a免费观看| 120秒试看无码体验区| 色偷偷一区二区无码视频| 国内老熟妇对白xxxxhd| 国产女人高潮视频在线观看| 久久亚洲中文无码咪咪爱| 精品乱码一区二区三四五区| 无码 制服 丝袜 国产 另类| 色猫咪av在线观看| 720lu国产刺激无码| 亚洲欧美成人一区二区在线电影 | 精品麻豆国产色欲色欲色欲www| 在线观看国产精品va| 欧美日韩亚洲精品瑜伽裤| 美女张开腿让男人桶爽| 国产亚洲福利在线视频| 国产成人综合久久免费| 一本色道久久综合亚洲精品| 少妇无码av无码专区线| 国产成人av无码永久免费一线天 | 男女性色大片免费网站| 亚洲另类无码专区国内精品| 热の综合热の国产热の潮在线| 特级做a爰片毛片免费看| 少妇粉嫩小泬喷水视频| 亚洲综合日韩久久成人av| 亚洲国产欧美日韩在线人成| 午夜精品久久久久久久| 国内偷自第一区二区三区| 欧美伦费免费全部午夜最新| 草草地址线路①屁屁影院成人| 国产精品无码mv在线观看 | 绝顶高潮合集videos| 国精品人妻无码一区二区三区d3| 男女扒开双腿猛进入免费看污| 国产精品一区二区av在线观看| 国产精品久久久久不卡绿巨人| 无套内射chinesehd熟女|