在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13)

In Stock
  • 中文名稱:
    人HSD17B13重組蛋白
  • 貨號:
    CSB-YP801815HU
  • 規(guī)格:
    ¥2208
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    HSD17B13
  • Uniprot No.:
  • 別名:
    HSD17B13; SCDR9; SDR16C3; HMFN0376; UNQ497/PRO1014; 17-beta-hydroxysteroid dehydrogenase 13; 17-beta-HSD 13; EC 1.1.-.-; Short chain dehydrogenase/reductase family 16C member 3; Short-chain dehydrogenase/reductase 9
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein of Isoform 2
  • 來源:
    Yeast
  • 分子量:
    34.8 kDa
  • 表達區(qū)域:
    20-300aa
  • 氨基酸序列
    ESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述:

    To produce recombinant Human HSD17B13 protein, a well-established recombinant DNA technology is the key. A DNA template of HSD17B13 was constructed with N-terminal 6xHis tag & C-terminal Myc tag using the technique. Once the template was made, the recombinant Human HSD17B13 protein could be produced with it efficiently. CUSABIO has built a strict QC system to ensure quality. The expression region is 20-300aa of the Human HSD17B13. The purity of this recombinant is 90% determined by SDS-PAGE.

    HSD17B13 (SCDR9) is a protein coding gene that encodes 17-beta-hydroxysteroid dehydrogenase 13. According to some studies, HSD17B13 may have the following features.
    Loss-of-function variants of HSD17B13 are associated with a reduced risk of chronic liver disease and progression from steatohepatitis to steatohepatitis. Inactivation of HSD17B13 was not associated with increased hepatic triglyceride content and provided protection against chronic liver disease. HSD17B13, a hepatic retinol dehydrogenase, is associated with histological features of nonalcoholic fatty liver disease. Lack of Hsd17b13 did not protect mice from an obesogenic diet. High risk of fatty liver amplifies the alanine aminotransferase-lowering effect of HSD17B13 variants. Genetic variants in HSD17B13 reduce the risk of cirrhosis and hepatocellular carcinoma in alcohol abusers.

  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻:
    1. Lower HSD17B13 in peritumoral tissues was associated with worse recurrence free survival and overall survival of hepatocellular carcinoma patients and altered G1/S progression of HCC cells. PMID: 29748147
    2. We conducted a test for association between the rs72613567:TA variant and protection against severe liver fibrosis in 88 patients of Caucasian descent with HCV monoinfection. We conclude that rs72613567:TA is correlated with protection against liver fibrosis associated with HCV infection. PMID: 30403944
    3. A loss-of-function variant in HSD17B13 was associated with a reduced risk of chronic liver disease and of progression from steatosis to steatohepatitis. PMID: 29562163
    4. 17beta-HSD13 as a pathogenic protein in the development of nonalcoholic fatty liver disease. PMID: 25028495
    5. A new human short-chain dehydrogenase/reductase gene SCDR9 is cloned and expressed. PMID: 17311113

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum. Lipid droplet.
  • 蛋白家族:
    Short-chain dehydrogenases/reductases (SDR) family
  • 組織特異性:
    Highly expressed in the liver. Also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18685

    OMIM: 612127

    KEGG: hsa:345275

    STRING: 9606.ENSP00000333300

    UniGene: Hs.284414



主站蜘蛛池模板: 97国产精品人妻无码久久久| 成人av一本不卡二卡| 国产美女遭强高潮网站下载| 久久狠狠色噜噜狠狠狠狠97| 人人妻人人澡人人爽久久av| 亚洲中文字幕日产乱码在线| 亚洲精品拍拍央视网出文| 日本乱码一区二区三区不卡| 午夜亚洲福利在线老司机| 亚洲熟女一区二区三区| 欧美 亚洲 国产 另类| 2020久久国产综合精品swag| 国产a v高清一区二区三区| 国产男女猛烈无遮挡免费视频网站| 欧美 日韩 人妻 高清 中文| 国产精品卡1卡2卡三卡四| 国产日产欧产精品精品app| 久久综合给久久狠狠97色| 国产露脸150部国语对白| 久久久精品人妻一区二区三区 | 亚洲一区二区三区香蕉| 三上悠亚精品一区二区久久 | 国产猛男猛女超爽免费视频| 亚洲国产成人久久综合人| 九九99久久精品在免费线18| 五十路丰满中年熟女中出| 人人妻人人澡人人爽久久av| 中文字幕日本最新乱码视频 | 天天槽夜夜槽槽不停| 一本一久本久a久久精品综合 | 久久久久久久综合日本| 性高湖久久久久久久久aaaaa| 久久久久久人妻一区精品| 国产精品欧美成人片| 熟妇人妻无乱码中文字幕| 92国产精品午夜福利| 在线涩涩免费观看国产精品| 国产97人妻人人做人碰人人爽| 日本高清色倩视频在线观看| 小12萝裸体视频国产| 人人爽人人澡人人人妻、百度|