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  4. Recombinant Histone-lysine N-methyltransferase mes-2 (mes-2), partial

Recombinant Histone-lysine N-methyltransferase mes-2 (mes-2), partial

  • 中文名稱：
    秀麗隱桿線蟲mes-2重組蛋白
  • 貨號：
    CSB-YP515708CXY
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲mes-2重組蛋白
  • 貨號：
    CSB-EP515708CXY
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲mes-2重組蛋白
  • 貨號：
    CSB-EP515708CXY-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲mes-2重組蛋白
  • 貨號：
    CSB-BP515708CXY
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲mes-2重組蛋白
  • 貨號：
    CSB-MP515708CXY
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    mes-2
  • Uniprot No.：
  • 別名：
    mes-2; R06A4.7; Histone-lysine N-methyltransferase mes-2; EC 2.1.1.356; E(z) homolog; Maternal-effect sterile protein 2
  • 種屬：
    Caenorhabditis elegans
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Polycomb group (PcG) protein. Catalytic subunit of a the mes-2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. In association with the nfya-1-NF-Y complex, may play a role in repressing the expression of the homeobox protein egl-5 in tissues such as the head. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells. Required for small-RNA-induced H3K27 trimethylation. Involved in the negative regulation of lifespan in a germline-independent fashion.
  • 基因功能參考文獻：
    1. mes-2 mutants suppress mab-3. PMID: 12791262
    2. mes-2 represses Hox expression, causing anteroposterior transformations and disrupts Hox-dependent neuroblast migration. PMID: 12791273
    3. The SET domain of MES-2 functions as a histone h3 methyltransferase in X chromosome inactivation. PMID: 15380065
    4. mes-2 orchestrates large-scale changes in chromatin organization and gene expression to promote the timely loss of developmental plasticity. PMID: 19460346
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily
  • 組織特異性：
    In adults, it is predominantly expressed in the germline, and weakly expressed in intestinal cells. Expressed in the hypoderm.
  • 數據庫鏈接：

    KEGG: cel:CELE_R06A4.7

    STRING: 6239.R06A4.7

    UniGene: Cel.19654



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