在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Halichoerus grypus Leptin (LEP)

  • 中文名稱:
    Recombinant Halichoerus grypus Leptin(LEP)
  • 貨號:
    CSB-YP012870HAU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Halichoerus grypus Leptin(LEP)
  • 貨號:
    CSB-EP012870HAU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Halichoerus grypus Leptin(LEP)
  • 貨號:
    CSB-EP012870HAU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Halichoerus grypus Leptin(LEP)
  • 貨號:
    CSB-BP012870HAU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Halichoerus grypus Leptin(LEP)
  • 貨號:
    CSB-MP012870HAU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    LEP; OBLeptin; Obesity factor
  • 種屬:
    Halichoerus grypus (Gray seal)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    22-167
  • 氨基酸序列
    MPIQRVQDD TKTLIKTIIT RINDISPPQG VCSRPRVAGL DFIPRVQSVR TLSGMDQILA TYQQILTSLQ SRSVVQIAND LANLRALLRL LASAKSCPVP RARGSDTIKG LGNVLRASVH STEVVALSRL KAALQDMLRQ LDRNPGC
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation.
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Leptin family


主站蜘蛛池模板: 国产乱人伦无无码视频试看| 性色av无码专区一ⅴa亚洲| 国产亚洲日韩欧美另类丝瓜app | 亚洲性人人天天夜夜摸| 亚洲视频高清不卡在线观看 | 国产欧美在线观看不卡| 欧美三级不卡在线观看| 好了av在线第四综合网站| 国产av成人无码精品网站| 国产欧美va欧美va香蕉在线 | 亚洲成av人在线视| 欧美黑人欧美精品刺激| 亚洲国产成人久久综合同性| 成人无码a∨电影免费| 免费无码又爽又刺激高潮的视频| 老熟女重囗味hdxx69| 无码国产欧美一区二区三区不卡| 国产一区二区三区在线电影| 欧美日产国产精品日产| 国内精品九九久久精品| 最近中文2019字幕第二页| 丁香五月亚洲中文字幕| 少妇愉情理伦片bd| 婷婷久久综合九色综合88| 日韩高清亚洲日韩精品一区| 久久久久久久久久久免费精品| 久久久一本精品99久久精品88| 亚洲午夜久久久影院伊人| 男人女人午夜视频免费| 国产日韩在线视看高清视频手机| 上海少妇高潮狂叫喷水了| 欧美成人精品三级网站| 成人国产mv免费视频| 亚洲国产精品无码久久一区二区| 欧美日韩精品一区二区在线观看| 无码人妻久久久一区二区三区| 欧美牲交a欧美牲交aⅴ免费下载| av无码电影一区二区三区| 2021自拍偷在线精品自拍偷| 亚洲国产精品无码久久98| 国产丝袜足j在线视频播放|