在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Halichoerus grypus Leptin (LEP)

  • 中文名稱:
    Recombinant Halichoerus grypus Leptin(LEP)
  • 貨號:
    CSB-YP012870HAU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Halichoerus grypus Leptin(LEP)
  • 貨號:
    CSB-EP012870HAU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Halichoerus grypus Leptin(LEP)
  • 貨號:
    CSB-EP012870HAU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Halichoerus grypus Leptin(LEP)
  • 貨號:
    CSB-BP012870HAU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Halichoerus grypus Leptin(LEP)
  • 貨號:
    CSB-MP012870HAU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    LEP; OBLeptin; Obesity factor
  • 種屬:
    Halichoerus grypus (Gray seal)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    22-167
  • 氨基酸序列
    MPIQRVQDD TKTLIKTIIT RINDISPPQG VCSRPRVAGL DFIPRVQSVR TLSGMDQILA TYQQILTSLQ SRSVVQIAND LANLRALLRL LASAKSCPVP RARGSDTIKG LGNVLRASVH STEVVALSRL KAALQDMLRQ LDRNPGC
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation.
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Leptin family


主站蜘蛛池模板: 色综合欧美亚洲国产| 精品人伦一区二区三区蜜桃免费| 亚洲精品无码永久在线观看性色| 天天综合天天爱天天做| 国产精品久久国产精品99盘| 69堂人成无码免费视频果冻传媒| 国产国拍精品av在线观看按摩| 亚洲狠狠婷婷综合久久| 人妻少妇heyzo无码专区| 婷婷五月深爱憿情网| 国产无套内射又大又猛又粗又爽| 狠狠色狠狠人格综合| 国产成人综合一区人人| 性xxxx欧美老妇506070| 成熟丰满熟妇av无码区| 久久亚洲美女精品国产精品| 亚洲成在人线a免费77777| 97av麻豆蜜桃一区二区| 内射后入在线观看一区| 男女作爱免费网站| 人妻精品国产一区二区| 人妻精品动漫h无码网站| 中文字幕无码av免费久久| 久久久久久久久久久久| 人妻少妇av无码一区二区| 精品国内综合一区二区| 少妇的渴望hd高清在线播放| 久久精品国产导航| 亚洲人成电影网站色| 国产av国片精品一区二区| 国产精品日本一区二区不卡视频| 和岳每晚弄的高潮嗷嗷叫视频| 秋霞电影网午夜鲁丝片无码| 久久国内精品自在自线图片| 中文字幕一区二区三区四区五区| 国产麻豆精品一区| 国产 高潮 抽搐 正在播放| 国产综合18久久久久久| 福利cosplayh裸体の福利| 国产成人综合亚洲色就色| 久久大香线蕉国产精品免费|