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  4. Recombinant Guanine nucleotide-binding protein alpha-3 subunit (gpa-3)

Recombinant Guanine nucleotide-binding protein alpha-3 subunit (gpa-3)

  • 中文名稱：
    秀麗隱桿線蟲gpa-3重組蛋白
  • 貨號：
    CSB-YP328771CXY
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲gpa-3重組蛋白
  • 貨號：
    CSB-EP328771CXY
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲gpa-3重組蛋白
  • 貨號：
    CSB-EP328771CXY-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲gpa-3重組蛋白
  • 貨號：
    CSB-BP328771CXY
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲gpa-3重組蛋白
  • 貨號：
    CSB-MP328771CXY
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    gpa-3
  • Uniprot No.：
  • 別名：
    gpa-3; E02C12.5; Guanine nucleotide-binding protein alpha-3 subunit
  • 種屬：
    Caenorhabditis elegans
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-354
  • 氨基酸序列
    GLCQSAEDK ELTLKSKAID KEMMQNHMSQ QKVVKLLLLG AGECGKSTVL KQMRILHDHG FTAEEAEQQK SVVFNNTLQA MTAILKGMEA LRMTFDKPIR ENDAKFVMES HKMLQEAKVF PEELANAIQA LWNDKAVQQV IAKGNEFQMP ESAPHFLSSL DRIKLPDYNP TEQDILLSRI KTTGIVEVKF QMKSVDFRVF DVGGQRSERK KWIHCFEDVN AIIFIAAISE YDQVLFEDET TNRMIESMRL FESICNSRWF INTSMILFLN KKDLFAEKIK RTSIKSAFPD YKGAQTYDES CRYIEEKFDG LNANPEKTIY MHQTCATDTD QVQMILDSVI DMIIQANLQG CGLY
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Promotes transcription of 3',5'-cyclic phosphodiesterases pde-1 and pde-5, leading to reduced cGMP levels in sensory neurons. This causes suppression of insulin production and signaling which leads to increased daf-16 activity and contributes to increased adult lifespan and resistance to oxidative stress. In addition, by reducing cGMP levels, inhibits TGF-beta signaling pathways. Involved in behavioral response to P.aeruginosa by controlling the expression of daf-7, a member of the TGF-beta family, in ASJ sensory neurons. Plays a role in the avoidance response to the noxious chemical quinine in ASH sensory neurons.
  • 基因功能參考文獻：
    1. A genetic screen revealed that GPA-3 regulates body fat content in the intestine. Pheromone ascr#3 regulates body fat stores in a GPA-3-dependent manner. PMID: 28545126
    2. Two G protein alpha subunits GPA-3 and ODR-3, expressed in ASH and in different, nonoverlapping sets of sensory neurons, are necessary for the response to quinine PMID: 14988722
  • 蛋白家族：
    G-alpha family, G(q) subfamily
  • 數據庫鏈接：


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