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  4. Recombinant Glutamate receptor 1 (glr-1), partial

Recombinant Glutamate receptor 1 (glr-1), partial

  • 中文名稱：
    秀麗隱桿線蟲glr-1重組蛋白
  • 貨號：
    CSB-YP009898CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲glr-1重組蛋白
  • 貨號：
    CSB-EP009898CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲glr-1重組蛋白
  • 貨號：
    CSB-EP009898CXY-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲glr-1重組蛋白
  • 貨號：
    CSB-BP009898CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲glr-1重組蛋白
  • 貨號：
    CSB-MP009898CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    glr-1
  • Uniprot No.：
  • 別名：
    glr-1; C06E1.4Glutamate receptor 1
  • 種屬：
    Caenorhabditis elegans
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. May contribute to a sensory discrimination between mechanical and chemical stimuli. Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response. In AIB interneurons, promotes omega turns, a movement that frequently follows backwards locomotion or 'reversals' in response to environmental cues while possibly playing an inhibitory role in alternative neurons to inhibit omega turns.
  • 基因功能參考文獻：
    1. We also assessed ionotropic glutamate receptor GLR-1 cell-specifically within AIB and determined that GLR-1 fine-tunes AIB activity to modify locomotion following reversal events. Our research highlights that signal integration underlying the initiation and fine-tuning of backwards locomotion is AIB and NPR-9 dependent, and has demonstrated the suitability of C. elegans for analysis of multisensory integration PMID: 27223098
    2. We propose a model in which synaptic activity regulates the nuclear localization of CMK-1 to mediate a negative feedback mechanism coupling GLR-1 activity with its own transcription. PMID: 27462879
    3. Mutants lacking p38 MAPK components pmk-1 or sek-1 resemble mutants lacking the hypoxia response component and prolyl hydroxylase egl-9, with impaired subcellular localization of Mint orthologue LIN-10, internalization of glutamate receptor GLR-1, and depression of GLR-1-mediated behaviors. PMID: 26731517
    4. KEL-8 is a substrate receptor for Cullin 3 ubiquitin ligases that is required for the proteolysis of GLR-1 receptors and suggest a novel postmitotic role in neurons for Kelch/CUL3 ubiquitin ligases. PMID: 16394099
    5. glr-1 is required for long-term memory for habituation and memory for context conditioning. PMID: 23013276
    6. Study indicates kinesin KLP-4 as a novel regulator of anterograde GLR-1 glutamate receptors trafficking and reveals a cellular control mechanism by which receptor cargo is targeted for degradation in tje absence of its motor. PMID: 22855524
    7. An auxiliary protein SOL-2, a CUB-domain protein, associates with both the related auxiliary subunit SOL-1 and with the GLR-1 AMPA receptor. PMID: 22958824
    8. Long-term memory in C. elegans is dependent on glr-1 and likely involves changes in the expression or localization of glutamate receptors PMID: 14573539
    9. SOL-1 participates in the gating of non-NMDA (N-methyl-D-aspartate) iGluRs, thereby providing a previously unknown mechanism of regulation for this class of neurotransmitter receptor PMID: 14749834
    10. GLR-1 is regulated in a homeostatic manner and this effect depends on clathrin-mediated endocytosis. PMID: 14981253
    11. A critical period for the 3-day enhanced behavior and ionotropic glutamate receptor distribution was observed in first larval stage worms, whereas there was no critical period for the depressed effects observed in 5-day-old worms. PMID: 17054718
    12. CDK-5 promotes the anterograde trafficking of GLR-1 and that phosphorylation of LIN-10 may play a role in this process. PMID: 17671168
    13. GLR-1-mediated avoidance behaviors are completely disrupted in stg-1;stg-2 double mutants, and GLR-1-mediated currents are absent, despite apparently normal surface expression of GLR-1. PMID: 18817737
    14. RPM-1 and PMK-3/p38 MAPK have roles in regulating the endosomal trafficking of AMPARs at central synapses PMID: 19172179

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  • 亞細胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Cell junction, synapse. Cell membrane. Recycling endosome. Cell projection, dendrite. Perikaryon.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family
  • 組織特異性：
    Command interneurons of the locomotory control circuit (AIB, AVA, AVB, AVD, AVE and PVC) and motor neurons (RMD, RIM, SMD, AVG, PVQ and URY).
  • 數據庫鏈接：

    KEGG: cel:CELE_C06E1.4

    STRING: 6239.C06E1.4

    UniGene: Cel.6005



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