在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Escherichia coli Outer membrane protein tolC (tolC), partial

Recombinant Escherichia coli Outer membrane protein tolC (tolC), partial

  • 中文名稱：
    大腸桿菌tolC重組蛋白
  • 貨號：
    CSB-YP355904ENV1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大腸桿菌tolC重組蛋白
  • 貨號：
    CSB-EP355904ENV1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大腸桿菌tolC重組蛋白
  • 貨號：
    CSB-EP355904ENV1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大腸桿菌tolC重組蛋白
  • 貨號：
    CSB-BP355904ENV1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大腸桿菌tolC重組蛋白
  • 貨號：
    CSB-MP355904ENV1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    tolC
  • Uniprot No.：
  • 別名：
    tolC; colE1-i; mtcB; mukA; refI; toc; weeA; b3035; JW5503; Outer membrane protein TolC; Multidrug efflux pump subunit TolC; Outer membrane factor TolC
  • 種屬：
    Escherichia coli (strain K12)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells.
  • 基因功能參考文獻：
    1. TolC, a potentially interesting pharmaceutical target can be addressed by small molecules, blocking the channel. Biophysical characterization of the binding processes will support future identification and optimisation of more potent TolC blockers in order to validate TolC as a pharmaceutical target. PMID: 28746830
    2. The authors report the near-atomic resolution cryoEM structures of the Escherichia coli AcrAB-TolC multidrug efflux pump in resting and drug transport states, revealing a quaternary structural switch that allosterically couples and synchronizes initial ligand binding with channel opening. PMID: 28355133
    3. A number of multi-drug efflux genes, particularly the central component TolC, show higher expression in antibiotic resistant Escherichia coli. PMID: 27105118
    4. Data suggest that outer membrane channel TolC plays an important role in extrusion of isoprenol and other medium-chain alcohols (CmOHs). PMID: 26563610
    5. Thus, tolC mutants grown in low iron conditions accumulate periplasmic enterobactin, which impairs bacterial morphology, possibly by sequestering iron and inhibiting an iron-dependent reaction involved in cell division or peptidoglycan synthesis. PMID: 24330203
    6. Interactions between TolC and AcrAB are highly dynamic and only a small fraction of TolC is utilized to support efflux activities. PMID: 23331412
    7. The TolC enhancement of extreme-acid survival includes Gad induction, but TolC-dependent growth rates below pH 6.5 do not involve Gad. PMID: 21541325
    8. These results indirectly suggest that TolC and YiaT proteins may play some role(s) in multidrug resistance. PMID: 20639525
    9. Inactivation of TolC triggers metabolic shutdown in E. coli cells grown in minimal glucose medium. PMID: 20545840
    10. essential for enterobactin export across the outer membrane PMID: 16166532
    11. The mechanism of tetracycline resistance was studied using expression studies in E. coli mutants that were defective in the tet(A) and the tolC proteins. PMID: 16687460
    12. Dada show that a combination of sbmA and tolC mutations appears to have additive effect, resulting in almost complete suppression of the phenotypic expression of Tn10 tetracycline resistance. PMID: 18083810
    13. Results describe two crystal structures of the Escherichia coli outer membrane protein TolC in its partially open state. PMID: 18406332
    14. TolC-dependent efflux system is involved in the exclusion of porphyrins in E. coli. PMID: 18641137
    15. The authors conclude that TolC plays an important role in L: -cysteine tolerance probably due to its export ability and that TolC overexpression is effective for L-cysteine production in E. coli. PMID: 18828007
    16. Data that TolC is involved in the efflux of certain cellular metabolites that accumulate during growth and trigger the upregulation of MarA, SoxS, and Rob, which in turn upregulate tolC and help rid the bacteria of these metabolites. PMID: 19502391

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell outer membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Outer membrane factor (OMF) (TC 1.B.17) family
  • 數據庫鏈接：


主站蜘蛛池模板： 六月丁香综合在线视频| 国产在视频线精品视频| 肉大榛一进一出免费视频| 亚洲 另类 在线 欧美 制服| 人摸人人人澡人人超碰97| 藏春阁福利视频| 人人澡超碰碰97碰碰碰| 九九热线有精品视频| 国产999久久高清免费观看 | 久久久久欧美精品| 久久久喷潮一区二区三区| 国产福利在线永久视频| 在线看亚洲十八禁网站| 国产精品久久久久久| 国产精品无打码在线播放| 国产成人精品日本亚洲语音| 日本高清视频在线www色| 日本又色又爽又黄的a片吻戏| 亚洲中文字幕伊人久久无码| 尤物精品国产第一福利网站| 亚洲va国产va天堂va久久| 亚洲欧美国产成人综合欲网| 狼友网精品视频在线观看| 久爱www人成免费网站| 国产区精品福利在线社区| 丁香五香天堂网| 欧美破苞系列二十三| 人妻av中文字幕一区二区三区| 久久久久久夜精品精品免费啦| 亚洲国产精品久久精品| 免费毛片a线观看| 爆乳一区二区三区无码| 成av人片一区二区三区久久| 色狠狠色噜噜av天堂一区| 2020精品国产视| 国产在线拍揄自揄拍无码视频| 亚洲色偷偷色噜噜狠狠99网| 亚洲精品欧美综合四区| 亚洲色中文字幕无码av| 精品国产sm最大网站| 色一情一伦一区二区三|