在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Escherichia coli Methyl-accepting chemotaxis protein I (tsr), partial

  • 中文名稱:
    大腸桿菌tsr重組蛋白
  • 貨號(hào):
    CSB-YP355908ENV
  • 規(guī)格:
    ¥2616
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    tsr
  • Uniprot No.:
  • 別名:
    tsr; cheD; b4355; JW4318Methyl-accepting chemotaxis protein I; MCP-I; Serine chemoreceptor protein
  • 種屬:
    Escherichia coli (strain K12)
  • 蛋白長度:
    Cytoplasmic Domain
  • 來源:
    Yeast
  • 分子量:
    38.0kDa
  • 表達(dá)區(qū)域:
    211-551aa
  • 氨基酸序列
    WFGIKASLVAPMNRLIDSIRHIAGGDLVKPIEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNAENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEMDRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQQQQRETSAVVKTVTPAAPRKMAVADSEENWETF
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Receptor for the attractant L-serine and related amino acids. Is also responsible for chemotaxis away from a wide range of repellents, including leucine, indole, and weak acids.; Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.
  • 基因功能參考文獻(xiàn):
    1. this study shows that Tsr interacts with IL-8 provoking E. coli transmigration across human lung epithelial cells PMID: 27506372
    2. results indicate that, rather than being essential for proper receptor-receptor interaction, the "glycine hinge" residues are involved in the ability of the receptor to switch between different signaling states. Mainly, the C-helix residue G439 has a key role in shifting the equilibrium toward a kinase-activating conformation. PMID: 28664727
    3. These results indicate that the E402 and R404 residues of Tsr play their most critical signaling roles at their inner locations near the trimer axis where they likely participate in stabilizing the trimer-of-dimer packing and the kinase-ON state of core signaling complexes. PMID: 28215934
    4. The authors suggest that the Tsr control cable transmits input signals to a four-helix HAMP bundle by modulating the intensity of structural clashes between out-of-register transmembrane helix and AS1 helix of HAMP. PMID: 27019297
    5. Phe396 governs conformational changes of tsr. PMID: 24335957
    6. Alterations in the symmetry of the two branches of the cytoplasmic hairpin of tsr seriously compromise chemoreceptor function. PMID: 22111959
    7. Mutant Tsr molecules with a charged amino acid or proline replacement exhibited the most severe trimer formation defects. PMID: 21965562
    8. The results suggest a helix extension mechanism of Tsr transmembrane signaling in which TM2 piston motions influence HAMP stability by modulating the helicity of the control cable segment. PMID: 21803986
    9. The findings of this study provide strong support for a three-state dynamic bundle model of HAMP domain signalling in Tsr, and possibly in other bacterial transducers as well. PMID: 21306449
    10. serine ligand binding increased rate of methylation PMID: 15516567
    11. Tsr responds to changes in proton motive force PMID: 16995896
    12. Architecture of receptor assemblies is in intact Escherichia coli is described. PMID: 17327165
    13. Most I241 lesions locked Tsr signal output in the kinase-on mode, implying that this residue is responsible mainly for stabilizing the kinase-off signaling state. PMID: 18621896
    14. The current study, utilizing a Tsr-GFP fusion protein and time-lapse fluorescence microscopy of individual cell lineages, demonstrates that Tsr accumulates approximately linearly with time at the cell poles PMID: 18647166
    15. Expansion of polyQ to 13Q in Tsr has no significant effect on chemotaxis. PMID: 18667570
    16. Amino acid replacements of two conserved residues at the tip of the trimer contact region of Tsr caused differing interactions with CheA and CheW. PMID: 18931127
    17. chemoreceptors are organized as trimers of receptor dimers and display two distinct conformations that differ principally in arrangement of the HAMP domains within each trimer PMID: 18940922
    18. The authors propose that Tsr HAMP controls output signals by modulating destabilizing phase clashes between the AS2 helices and the adjoining kinase control helices. PMID: 19656294

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell inner membrane; Multi-pass membrane protein. Note=Found predominantly at cell poles.
  • 數(shù)據(jù)庫鏈接:

    KEGG: ecj:JW4318

    STRING: 316407.85677095



主站蜘蛛池模板: 久久精品www人人做人人爽| 在线综合亚洲欧美日韩| 秋霞最新高清无码鲁丝片| 精品人妻伦一二三区久久aaa片| 久久亚洲精品成人无码网站夜色 | 亚洲va久久久噜噜噜久久4399| 亚洲人成77777在线播放网站| 精品无码国产自产在线观看水浒传 | 玩弄少妇人妻| 久久伊人精品波多野结衣| 99999久久久久久亚洲| 亚洲精品久久久久久久蜜桃臀 | 伊人www22综合色| 亚洲自偷自偷在线成人网址| 99这里有精品视频视频| 成人女人看片免费视频放人| 大学生高潮无套内谢视频| 亚洲国产成人精品无码区在线秒播| 久久国产乱子精品免费女| 东京热久久综合久久88| 7777久久亚洲中文字幕| 国产精品高清一区二区不卡片| 午夜精品射精入后重之免费观看| 亚洲欧美日韩精品久久| 免费又黄又爽1000禁片| 亚洲综合久久无码色噜噜赖水| 在线天堂最新版资源| 天天做天天爱夜夜夜爽毛片| 亚欧洲精品在线视频免费观看| 又爽又色禁片1000视频免费看| 国产成人不卡无码免费视频| 三级4级全黄60分钟| 少妇愉情理伦片丰满丰满午夜| 国产美女亚洲精品久久久| 被拉到野外强要好爽黑人| 欧美日韩视频无码一区二区三| 亚洲欧洲成人av每日更新| 欧美熟妇性xxxx交潮喷| 色婷婷综合缴情综免费观看| 夜夜爽一区二区三区精品| 免费国产成人午夜福利电影|