在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Escherichia coli A/G-specific adenine glycosylase (mutY)

  • 中文名稱:
    大腸桿菌mutY重組蛋白
  • 貨號(hào):
    CSB-YP323807ENV
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱:
    大腸桿菌mutY重組蛋白
  • 貨號(hào):
    CSB-EP323807ENV
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱:
    大腸桿菌mutY重組蛋白
  • 貨號(hào):
    CSB-EP323807ENV-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    大腸桿菌mutY重組蛋白
  • 貨號(hào):
    CSB-BP323807ENV
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱:
    大腸桿菌mutY重組蛋白
  • 貨號(hào):
    CSB-MP323807ENV
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    mutY
  • Uniprot No.:
  • 別名:
    mutY; micA; b2961; JW2928; Adenine DNA glycosylase; EC 3.2.2.31; A/G-specific adenine glycosylase
  • 種屬:
    Escherichia coli (strain K12)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-350
  • 氨基酸序列
    MQASQFSAQV LDWYDKYGRK TLPWQIDKTP YKVWLSEVML QQTQVATVIP YFERFMARFP TVTDLANAPL DEVLHLWTGL GYYARARNLH KAAQQVATLH GGKFPETFEE VAALPGVGRS TAGAILSLSL GKHFPILDGN VKRVLARCYA VSGWPGKKEV ENKLWSLSEQ VTPAVGVERF NQAMMDLGAM ICTRSKPKCS LCPLQNGCIA AANNSWALYP GKKPKQTLPE RTGYFLLLQH EDEVLLAQRP PSGLWGGLYC FPQFADEESL RQWLAQRQIA ADNLTQLTAF RHTFSHFHLD IVPMWLPVSS FTGCMDEGNA LWYNLAQPPS VGLAAPVERL LQQLRTGAPV
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
  • 基因功能參考文獻(xiàn):
    1. Studies indicate that the DNA repair gene MUTYH, which is a homologue of the E. coli gene mutY, is responsible for colorectal carcinoma (CRC). PMID: 23933175
    2. MutY mutations reduced the point-mutation rate by 40-60%. PMID: 23248287
    3. ability of MUTYH and the variants to suppress mutations and complement for the absence of MutY in Escherichia coli was assessed using rifampicin resistance assays. PMID: 19836313
    4. catalytic analysis of Escherichia coli MutY DNA glycosylase PMID: 15326180
    5. Mutant MutY(Delta26-134), which lacks the six-helix barrel domain, cannot complement the mutator phenotype of a mutY mutant in vivo. However, the mutant can still bind DNA and has weak catalytic activity at high enzyme concentrations. PMID: 15456766
    6. Electrochemical measurement of MutY using DNA-modified electrodes demonstrates that this base excision repair enzyme containing a [4Fe-4S] cofactor is redox-active when bound to DNA. PMID: 15938629
    7. 8-oxoG-derived lesions are equally miscoding when replicated in E. coli lacking MutY; no significant change in mutation identity or frequency is observed. Yet, in the presence of MutY, Sp1 and Sp2 are more toxic than in cells lacking this repair enzyme PMID: 17260974
    8. Data show a lack of interaction of mutY with dnaX36 since the double dnaX36 mutY strains did not show any major changes in the frequency of G.CT.A transversions compared to the single dnaX36 strain. PMID: 18156258
    9. HPs and SSAs are a common finding in MAP patients. The detection of almost exclusively G:C-->T:A transversions in the K-ras gene of HPs/SSAs strongly suggests that these polyps are related causally to MYH deficiency. PMID: 19013464
    10. V45A and Q182L mutants had reduced binding for A/G and A/8-oxoG mismatches and increased affinities towards T/G mismatch. PMID: 19523222

    顯示更多

    收起更多

  • 蛋白家族:
    Nth/MutY family
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 未满小14洗澡无码视频网站| 精国产品一区二区三区a片| 欧美午夜理伦三级在线观看| 久久人妻无码aⅴ毛片a片app| 美乳丰满人妻无码视频| 亚洲人成人一区二区三区| 亚洲自偷自拍另类小说| 亚洲色成人网站www永久| 少妇饥渴xxhd麻豆xxhd骆驼| 四虎国产精品永久免费网址| 精品偷拍被偷拍在线观看| 欧美丰满大爆乳波霸奶水多| 日韩成人大屁股内射喷水| 久久久亚洲欧洲日产国码是av| 国产丰满老熟女重口对白| 欧美专区日韩视频人妻| 中日韩va无码中文字幕| 久久香蕉国产线看观看猫咪av| 99久久婷婷国产综合精品青草免费 | 在线黑人抽搐潮喷| 国产免费艾彩sm调教视频| 在线无码中文字幕一区| 特级小箩利无码毛片| 国产成人啪精品午夜网站a片免费| 第九色区av天堂| 午夜福利国产成人无码gif动图| 丰满少妇大叫太大太粗| 天堂资源在线www在线观看| 在线成人精品国产区免费| 亚洲欧美日韩精品色xxx| 妺妺跟我一起洗澡没忍住| 伊人大杳焦在线| 欧美搡bbbbb搡bbbbb| 国产熟妇高潮叫床视频播放| 中文字幕三级人妻无码视频| 高清同性男毛片| 日韩欧群交p片内射中文| 国产精品秘入口18禁麻豆免会员| av狼友无码国产在线观看| av一区二区国产在线视频| 中出内射颜射骚妇|