在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Escherichia coli A/G-specific adenine glycosylase (mutY)

  • 中文名稱:
    大腸桿菌mutY重組蛋白
  • 貨號(hào):
    CSB-YP323807ENV
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱:
    大腸桿菌mutY重組蛋白
  • 貨號(hào):
    CSB-EP323807ENV
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱:
    大腸桿菌mutY重組蛋白
  • 貨號(hào):
    CSB-EP323807ENV-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    大腸桿菌mutY重組蛋白
  • 貨號(hào):
    CSB-BP323807ENV
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱:
    大腸桿菌mutY重組蛋白
  • 貨號(hào):
    CSB-MP323807ENV
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    mutY
  • Uniprot No.:
  • 別名:
    mutY; micA; b2961; JW2928; Adenine DNA glycosylase; EC 3.2.2.31; A/G-specific adenine glycosylase
  • 種屬:
    Escherichia coli (strain K12)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-350
  • 氨基酸序列
    MQASQFSAQV LDWYDKYGRK TLPWQIDKTP YKVWLSEVML QQTQVATVIP YFERFMARFP TVTDLANAPL DEVLHLWTGL GYYARARNLH KAAQQVATLH GGKFPETFEE VAALPGVGRS TAGAILSLSL GKHFPILDGN VKRVLARCYA VSGWPGKKEV ENKLWSLSEQ VTPAVGVERF NQAMMDLGAM ICTRSKPKCS LCPLQNGCIA AANNSWALYP GKKPKQTLPE RTGYFLLLQH EDEVLLAQRP PSGLWGGLYC FPQFADEESL RQWLAQRQIA ADNLTQLTAF RHTFSHFHLD IVPMWLPVSS FTGCMDEGNA LWYNLAQPPS VGLAAPVERL LQQLRTGAPV
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
  • 基因功能參考文獻(xiàn):
    1. Studies indicate that the DNA repair gene MUTYH, which is a homologue of the E. coli gene mutY, is responsible for colorectal carcinoma (CRC). PMID: 23933175
    2. MutY mutations reduced the point-mutation rate by 40-60%. PMID: 23248287
    3. ability of MUTYH and the variants to suppress mutations and complement for the absence of MutY in Escherichia coli was assessed using rifampicin resistance assays. PMID: 19836313
    4. catalytic analysis of Escherichia coli MutY DNA glycosylase PMID: 15326180
    5. Mutant MutY(Delta26-134), which lacks the six-helix barrel domain, cannot complement the mutator phenotype of a mutY mutant in vivo. However, the mutant can still bind DNA and has weak catalytic activity at high enzyme concentrations. PMID: 15456766
    6. Electrochemical measurement of MutY using DNA-modified electrodes demonstrates that this base excision repair enzyme containing a [4Fe-4S] cofactor is redox-active when bound to DNA. PMID: 15938629
    7. 8-oxoG-derived lesions are equally miscoding when replicated in E. coli lacking MutY; no significant change in mutation identity or frequency is observed. Yet, in the presence of MutY, Sp1 and Sp2 are more toxic than in cells lacking this repair enzyme PMID: 17260974
    8. Data show a lack of interaction of mutY with dnaX36 since the double dnaX36 mutY strains did not show any major changes in the frequency of G.CT.A transversions compared to the single dnaX36 strain. PMID: 18156258
    9. HPs and SSAs are a common finding in MAP patients. The detection of almost exclusively G:C-->T:A transversions in the K-ras gene of HPs/SSAs strongly suggests that these polyps are related causally to MYH deficiency. PMID: 19013464
    10. V45A and Q182L mutants had reduced binding for A/G and A/8-oxoG mismatches and increased affinities towards T/G mismatch. PMID: 19523222

    顯示更多

    收起更多

  • 蛋白家族:
    Nth/MutY family
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 亚洲精品55夜色66夜色| a一区二区三区乱码在线 | 欧洲| 亚洲日韩av一区二区三区四区 | 亚洲日韩乱码中文无码蜜桃臀| 爽爽精品dvd蜜桃成熟时电影院| 色妺妺av爽爽影院| 又色又爽又黄的美女裸体网站 | 免费人成视频在线播放视频| 欧洲lv尺码大精品久久久| 国产情侣真实露脸在线| 久久亚洲中文字幕精品一区| 天堂亚洲国产中文在线| 虎白女粉嫩尤物福利视频| 欧美金妇欧美乱妇xxxx| 色欲人妻aaaaaa无码| 男男又爽又黄又无遮挡网站| 九九久久精品无码专区| 少妇挑战黑人高潮惨叫| 高清国产亚洲欧洲av综合一区 | 成在线人永久免费视频播放 | 无套内谢少妇毛片aaaa片免费| 动漫精品视频一区二区三区| 午夜福利理论片在线观看| 大陆精大陆国产国语精品 | 国产精品久久久久影院老司| 一本本月无码-| 久久综合精品国产一区二区三区无码| 偷妻之寂寞难耐2中文字幕| 成 人免费va视频| 日本又色又爽又黄的视频免 | 动漫av永久无码精品每日更新| 国产乱子伦在线一区二区| 成年女性特黄午夜视频免费看| 亚洲伊人久久大香线蕉综合图片| 无码国产精成人午夜视频| 国产精品久久久久久久免费看| 伊人久久综合成人网| 国产在线观看高清视频黄网| 最近2019免费中文第一页| 天堂国产一区二区三区| 极品无码国模国产在线观看|