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  4. Recombinant Dynein light chain 1, cytoplasmic (dlc-1)

Recombinant Dynein light chain 1, cytoplasmic (dlc-1)

  • 中文名稱：
    秀麗隱桿線蟲dlc-1重組蛋白
  • 貨號：
    CSB-YP637558CXY
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲dlc-1重組蛋白
  • 貨號：
    CSB-EP637558CXY
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲dlc-1重組蛋白
  • 貨號：
    CSB-EP637558CXY-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲dlc-1重組蛋白
  • 貨號：
    CSB-BP637558CXY
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲dlc-1重組蛋白
  • 貨號：
    CSB-MP637558CXY
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    dlc-1
  • Uniprot No.：
  • 別名：
    dlc-1; T26A5.9Dynein light chain 1; cytoplasmic
  • 種屬：
    Caenorhabditis elegans
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-89
  • 氨基酸序列
    MVDRKAVIKN ADMSDDMQQD AIDCATQALE KYNIEKDIAA YIKKEFDKKY NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as a non-catalytic accessory component of a dynein complex. Part of a complex with bicd-1 and egal-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migrations in hypodermal precursor cells. Probably within a dynein motor complex, plays a role in the cell fate specification of the germline and oogenesis. In particular, it inhibits germ cell proliferation. Regulates the function and localization of the RNA-binding protein fbf-2 in the germline. Plays a role in mitotic and meiotic processes. Involved in the pairing of homologous chromosomes. Independently of its dynein-mediated functions, plays a role in germ cell apoptosis.
  • 基因功能參考文獻：
    1. DLC-1 directly binds to FBF-2 outside of the RNA-binding domain and promotes FBF-2 localization and function. This result identifies a new role for DLC-1 in post-transcriptional regulation of gene expression. PMID: 27864381
    2. DLC-1 is functioning cell nonautonomously through the same pathway as kri-1 in response to ionizing radiation-induced apoptosis. PMID: 24030151
    3. Dynein light chain 1 (DLC-1) and its partner, dynein heavy chain 1, inhibit the proliferative cell fate, in part through regulation of METT-10, a conserved putative methyltransferase. PMID: 19752194
  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Nucleus envelope. Cytoplasmic granule.
  • 蛋白家族：
    Dynein light chain family
  • 組織特異性：
    Broadly expressed in tissues including the intestine, body wall muscles, germs cells, oocytes, the rectal valve and cells in the head.
  • 數據庫鏈接：

    KEGG: cel:CELE_T26A5.9

    STRING: 6239.T26A5.9.2

    UniGene: Cel.18125



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