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  4. Recombinant Drosophila melanogaster Transient receptor potential cation channel protein painless (pain), partial

Recombinant Drosophila melanogaster Transient receptor potential cation channel protein painless (pain), partial

  • 中文名稱：
    黑腹果蠅pain重組蛋白
  • 貨號：
    CSB-YP894300DLU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅pain重組蛋白
  • 貨號：
    CSB-EP894300DLU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅pain重組蛋白
  • 貨號：
    CSB-EP894300DLU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅pain重組蛋白
  • 貨號：
    CSB-BP894300DLU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅pain重組蛋白
  • 貨號：
    CSB-MP894300DLU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    pain
  • Uniprot No.：
  • 別名：
    pain; CG15860Transient receptor potential cation channel protein painless
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius.
  • 基因功能參考文獻(xiàn)：
    1. Recent work has uncovered the painless, mediating fly thermosensation. PMID: 25616212
    2. For the regulation of sexual receptivity through Pain TRP channels. PMID: 24505416
    3. in the case of Painless, ankryin repeats are important for thermal nociception but not for mechanical nociception PMID: 22295071
    4. results indicate that functions of painless in the adult central nervous system of Drosophila include modulation of olfactory processing and inhibition of male-male courtship behavior PMID: 22073144
    5. Painless constitutes part of a mechanosensitive pathway that adjusts cardiac muscle activity to mechanical constraints. PMID: 20824071
    6. A transient receptor potential (TRP) channel family member, painless, plays a role in low- and high-temperature responses. PMID: 14585595
    7. The stinging sensation of isothiocyanate, the pungent ingredient of wasabi, is caused by activation of an evolutionarily conserved molecular pathway that is also used for nociception. PMID: 16647259
    8. Abnormal nociceptive behavior of a mutant, painless, indicates that painless, a gene essential for nociception in Drosophila larvae, is also required for thermal nociception in adult flies. PMID: 17081265
    9. We found that fructose potently elicited larval food-averse behaviors, and painless (pain), a transient receptor potential channel that is responsive to noxious stimuli, was required for the fructose response. PMID: 18469811
    10. Painless protein is a direct sensor for noxious heat in Drosophila; Painless mediates a robust intracellular divalent calcium ion increase during heating as well as heat-evoked inward currents in whole-cell patch-clamp mode. PMID: 18829951
    11. Our results suggest that Pain TRP channels expressed in cholinergic and/or GABAergic neurons are involved in female sexual receptivity. PMID: 19531155

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  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family
  • 組織特異性：
    Present in multidendritic neurons, chordotonal neurons, a subset of cells in the central nervous system and a subset of sensory neurons in the antennal-maxillary complex. Not detected in gonads and dorsal vessels (at protein level). Expressed in periphera
  • 數(shù)據(jù)庫鏈接：

    KEGG: dme:Dmel_CG15860

    STRING: 7227.FBpp0072323

    UniGene: Dm.14984



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