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  4. Recombinant Drosophila melanogaster Tissue inhibitor of metalloproteases (Timp)

Recombinant Drosophila melanogaster Tissue inhibitor of metalloproteases (Timp)

  • 中文名稱：
    黑腹果蠅Timp重組蛋白
  • 貨號：
    CSB-YP894223DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅Timp重組蛋白
  • 貨號：
    CSB-EP894223DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅Timp重組蛋白
  • 貨號：
    CSB-EP894223DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅Timp重組蛋白
  • 貨號：
    CSB-BP894223DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅Timp重組蛋白
  • 貨號：
    CSB-MP894223DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Timp
  • Uniprot No.：
  • 別名：
    Timp; CG6281; Tissue inhibitor of metalloproteinase
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    28-210
  • 氨基酸序列
    CSC MPSHPQTHFA QADYVVQLRV LRKSDTIEPG RTTYKVHIKR TYKATSEARR MLRDGRLSTP QDDAMCGINL DLGKVYIVAG RMPTLNICSY YKEYTRMTIT ERHGFSGGYA KATNCTVTPC FGERCFKGRN YADTCKWSPF GKCETNYSAC MPHKVQTVNG VISRCRWRRT QLYRKCMSNP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Metalloproteinase inhibitor that acts on both matrix metalloproteinases Mmp1 and Mmp2 in vitro. Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Required for wing maturation which is the final step in morphogenesis of the adult fly. Involved in the negative regulation of developmental tissue invasion for imaginal disk eversion during metamorphosis by inhibiting Mmp-mediated basement membrane (BM) degradation. Required for oogenesis and for the long-term maintainance of germarial structure and shape in the adult ovaries. Required for maintaining composition and biophysical properties of the extracellular matrix (ECM), and for the normal organization and cyst production of the germline stem cell (GSC) niche.
  • 基因功能參考文獻：
    1. Our results demonstrating a crucial role for timp in tissue organization and gamete production thus provide a link between the regulation of ECM metabolism and tissue homeostasis. PMID: 26808525
    2. identification as endogenous inhibitor of the Drosophila matrix metalloproteinases PMID: 14567681
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Protease inhibitor I35 (TIMP) family
  • 組織特異性：
    Expressed in heads of female and male adult flies. Expressed at the time of eclosion in unopened wings of adult flies. Strongly expressed at the tip of ovarian germarium region 1 where germline stem cells (GSCs) and cystoblasts reside and in region 2 of t
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG6281

    STRING: 7227.FBpp0081722

    UniGene: Dm.2453



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