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  4. Recombinant Drosophila melanogaster Sodium channel protein para (para), partial

Recombinant Drosophila melanogaster Sodium channel protein para (para), partial

  • 中文名稱：
    黑腹果蠅para重組蛋白
  • 貨號：
    CSB-YP327422DLU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅para重組蛋白
  • 貨號：
    CSB-EP327422DLU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅para重組蛋白
  • 貨號：
    CSB-EP327422DLU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅para重組蛋白
  • 貨號：
    CSB-BP327422DLU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅para重組蛋白
  • 貨號：
    CSB-MP327422DLU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    para
  • Uniprot No.：
  • 別名：
    para; CG9907; Sodium channel protein para; Protein paralytic; Sodium channel 1; DmNav1
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
  • 基因功能參考文獻：
    1. Study identified Shu, a Drosophila mutation causing severe behavioral defects, as a novel hypermorphic allele of the Nav channel gene para. Results suggest that the Shu Nav channels cause an increase in sodium currents, and that this defect is compensated by reduced para function, leading to a more balanced neuronal output. PMID: 27844061
    2. analysis revealed that 2 variant-specific amino acid changes, I260T in the S4-S5 linker of domain I (ILS4-S5) and A1731V in the voltage sensor S4 of domain IV (IVS4), contribute to the persistent sodium current (INaP) PMID: 24662849
    3. Trp404 and His405 as a putative point of Av3 interaction with DmNav1. PMID: 25055135
    4. The para(bss1) has not responded to seizure suppressor mutations identified in screens based on the Drosophila mutants eas protein and sda protein. PMID: 23797108
    5. results indicate that increased synaptic activity influences the decision to splice in exon L, which, in turn, may promote seizure. PMID: 22623672
    6. 3-dimensional structure modeling of ANEPII and site-4 of the insect sodium channel were carried out by homology modeling, and these models were used as the starting point for nanosecond-duration molecular dynamics simulations. PMID: 20816643
    7. Chromosome fusions from patterns of polymorphism at the X-linked para gene were studied. PMID: 12930752
    8. The structure of the scorpion alpha-toxin LqhalphaIT binding site in the para sodium channel of Drosophila melanogaster was characterized using NMR Spectroscopy. PMID: 18154318
    9. Drosomycin interacts with the voltage-gated sodium channel, DmNa(v)1. PMID: 19574227

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium channel (TC 1.A.1.10) family, Para subfamily
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG9907

    STRING: 7227.FBpp0303597

    UniGene: Dm.22809



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