在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Drosophila melanogaster Serine/threonine-protein kinase PLK4 (SAK), partial

Recombinant Drosophila melanogaster Serine/threonine-protein kinase PLK4 (SAK), partial

  • 中文名稱：
    黑腹果蠅SAK重組蛋白
  • 貨號：
    CSB-YP018196DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅SAK重組蛋白
  • 貨號：
    CSB-EP018196DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅SAK重組蛋白
  • 貨號：
    CSB-EP018196DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅SAK重組蛋白
  • 貨號：
    CSB-BP018196DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅SAK重組蛋白
  • 貨號：
    CSB-MP018196DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SAK
  • Uniprot No.：
  • 別名：
    SAK; CG7186; Serine/threonine-protein kinase PLK4; EC 2.7.11.21; Polo-like kinase 4; PLK-4; Serine/threonine-protein kinase SAK
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as Sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting the importance of centrosome regulation in cancers.
  • 基因功能參考文獻：
    1. Plk4 phosphorylates Cep135 to properly position the essential centriole component Asterless. PMID: 27558293
    2. Plk4 phosphorylates Ana2 at S38 and STAN motif and promotes Ana2 recruitment to the centriole. PMID: 29263250
    3. When Asl reduction is attenuated by Asl overexpression, plk4 mutations, Plk4 RNAi, or Slimb overexpression, Asl levels are higher in spermatozoa, resulting in embryos with reduced viability. PMID: 26480844
    4. Drosophila Plk4 phosphorylates four conserved serines in the STAN motif of the core centriole protein Ana2 to enable it to bind and recruit its Sas6 partner. PMID: 25264260
    5. Plk4 directly generates its own phosphodegron.Phosphorylation of only S293 of the Slimb-recognition motif is required for Slimb binding to Plk4. PMID: 24184097
    6. Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.PLK4 protein levels are controlled by Slimb. PMID: 24184099
    7. SAK/PLK4 is required for centriole duplication and flagella development. PMID: 16326102

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family, CDC5/Polo subfamily
  • 組織特異性：
    Expressed in testis (at protein level).
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG7186

    STRING: 7227.FBpp0078042

    UniGene: Dm.3240



主站蜘蛛池模板： 欧美综合精品久久久久成人影院| 国产福利在线永久视频| 欧美黑人又粗又大xxx| 亚洲va中文字幕无码一二三区| 中国熟妇人妻xxxxx| 久本草在线中文字幕亚洲| 69久久精品无码一区二区| 亚洲国产一卡2卡3卡4卡5公司| 又爽又色禁片1000视频免费看| 中国xxx农村性视频| 国精产品一区一区三区免费视频| 女人被狂c躁到高潮视频| 国产精品久久久久影院嫩草| 在线不卡日本v一区二区| 亚洲精品成人网线在线播放va| 欧美亚洲日本国产其他| 伴郎粗大的内捧猛烈进出视频观看| 精品国产乱码久久久久久1区2区 | 免费人成激情视频在线观看| 男女下面一进一出无遮挡 | 成人做爰69片免费看网站野花| 久久99热人妻偷产国产| 色狠狠一区二区三区香蕉| 成人精品动漫一区二区| 亚洲国产成人在人网站天堂| 欧洲美女粗暴牲交免费观看| 老司机亚洲精品影院| 激情射精爆插热吻无码视频| 中国熟妇内谢69xxxxx| 欧美三级在线播放| 亚洲国产欧美国产综合一区| 久久精品熟女亚州av麻豆| 欧美老肥熟妇多毛xxxxx| 奇米777四色影视在线看| av色综合久久天堂av色综合在| 久久亚洲精品ab无码播放| 蜜臀av色欲a片无码一区| 国产亚洲欧美日韩俺去了| 国产人妻一区二区三区久| 无码内射中文字幕岛国片| 国产亚洲熟妇综合视频|