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  4. Recombinant Drosophila melanogaster Segmentation polarity homeobox protein engrailed (en), partial

Recombinant Drosophila melanogaster Segmentation polarity homeobox protein engrailed (en), partial

  • 中文名稱：
    黑腹果蠅en重組蛋白
  • 貨號：
    CSB-YP360890DLU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅en重組蛋白
  • 貨號：
    CSB-EP360890DLU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅en重組蛋白
  • 貨號：
    CSB-EP360890DLU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅en重組蛋白
  • 貨號：
    CSB-BP360890DLU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅en重組蛋白
  • 貨號：
    CSB-MP360890DLU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    en
  • Uniprot No.：
  • 別名：
    en; CG9015; Segmentation polarity homeobox protein engrailed
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    This protein specifies the body segmentation pattern. It is required for the development of the central nervous system. Transcriptional regulator that represses activated promoters. Wg signaling operates by inactivating the SGG repression of EN autoactivation.
  • 基因功能參考文獻：
    1. Data show that the Distalless and Engrailed homeodomain transcription factors act through sequences in this enhancer to establish elevated Sex combs reduced (Scr) expression in spatially defined domains. PMID: 29634724
    2. these results suggest that En in Johnston's Organ neurons regulate both neuronal excitability and synaptic connectivity. PMID: 25164665
    3. Silencing Engrailedin Johnston's organ neurons reduces the sound-evoked potential amplitude at the onset of the stimulus by about half at 100, 200 and 400 Hz. PMID: 23940751
    4. This study showed that small subset of FRUM neurons distributed in the brain and ventral cord of males by their co-expression with in En neurons PMID: 23688386
    5. Our studies identified several abnormal phenotypes in live engrailed (en) mutant embryos prior to cycle 8. Nuclei in en embryos divide asynchronously, an abnormality that was detected as early as nuclear cycle 2-3. PMID: 23593026
    6. Polycomb group protein binding per se does not determine the transcriptional state of engrailed. PMID: 23139817
    7. During development of the Drosophila ocellar complex, engrailed (en) plays a role both as a target and as a transcriptional repressor of hedgehog (hh) signaling in the prospective interocellar region. PMID: 23154412
    8. Anterior crossvein formation requires En function. An extracellular pool of En protein is present in the wing disc that diffuses beyond its expression domain and is required for the formation of the anterior crossvein. PMID: 21558379
    9. Data suggests that engrailed folds to its native structure via an intermediate in which the HTH motif is formed, and that secondary structure development occurs first followed by tertiary packing. PMID: 21035367
    10. Role of en and novel interactions between msh, ind, and vnd in dorsoventral patterning of the Drosophila brain and ventral nerve cord PMID: 20673828
    11. high levels of Engrailed make the epidermal cells inhospitable to bristle neurons; sensory axons that are too near these cells are either deflected or fail to extend properly or at all PMID: 20667917
    12. electrostatics significantly affect the stability of designed homeodomain variants PMID: 11829512
    13. relationship between engrailed and dominant additional vein mutant PMID: 12502252
    14. En is a bifunctional transcription factor and the recruitment of additional cofactors presumably specifies which function prevails on an individual promoter. PMID: 12506003
    15. Folding pathway of the three-helix bundle protein Engrailed homeodomain PMID: 12594518
    16. crystal structures of engrailed homeodomain mutants PMID: 12923178
    17. Engrailed is responsible for the establishment of ci repression early during embryonic development and is also required to maintain the repression of ci throughout development. PMID: 15282166
    18. Engrailed's function during the segregation of the neuroblasts is crucial for regulating different actors that are later involved in axon guidance PMID: 17126316
    19. compartmental expression of Ubx and abd-A is established through a repressive regulatory network between en, slp, Ubx and abd-A PMID: 17573068
    20. Engrailed Polycomb-group response elements bring chromatin together, allowing both positive and negative regulatory interactions between distantly located DNA fragments. PMID: 18199580
    21. Molecular dynamics simulations were performed on an ultrafast unfolding and folding protein at its melting temperature to observe, on an atom-by-atom basis, the pathways the protein followed as it unfolded and folded within a continuous trajectory. PMID: 18553935
    22. Engrailed expression in subsets of adult Drosophila sensory neurons. PMID: 18597129
    23. Using a Drosophila model of Huntington's disease, we found that Engrailed (EN), a transcriptional activator of endogenous Drosophila htt (dhtt), is able to prevent aggregation of polyQ-hHtt. PMID: 18718937
    24. en expression is down-regulated in the posterior portion of wing discs, indicating that the PRC2 complex acts as an activator of en. PMID: 19368801
    25. Data show that engrailed enhancers can act over large distances, even skipping over other transcription units, choosing the engrailed promoter over those of neighboring genes. PMID: 19675130

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Engrailed homeobox family
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG9015

    STRING: 7227.FBpp0087197

    UniGene: Dm.22056



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