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  4. Recombinant Drosophila melanogaster Putative transcription factor capicua (cic), partial

Recombinant Drosophila melanogaster Putative transcription factor capicua (cic), partial

  • 中文名稱：
    Recombinant Drosophila melanogaster Putative transcription factor capicua(cic) ,partial
  • 貨號：
    CSB-YP866167DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Putative transcription factor capicua(cic) ,partial
  • 貨號：
    CSB-EP866167DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Putative transcription factor capicua(cic) ,partial
  • 貨號：
    CSB-EP866167DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Putative transcription factor capicua(cic) ,partial
  • 貨號：
    CSB-BP866167DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Putative transcription factor capicua(cic) ,partial
  • 貨號：
    CSB-MP866167DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    cic
  • Uniprot No.：
  • 別名：
    cic; fet; CG43122Putative transcription factor capicua; Protein fettucine
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcriptional repressor required for the specification of numerous cell types during embryonic development. Required for terminal patterning of early embryos. May associate with gro to repress tll and hkb, restricting their expression to embryonic terminal poles where they initiate correct development of head and tail structures. Required for dorsoventral patterning of oocytes and early embryos. Cooperates with dl to repress zen and other dorsal specific genes within the embryo and promotes expression of the ventralizing factor pip in ovarian follicle cells. Required during wing development for the specification of intervein areas, where it mediates localized repression of vein specific genes such as aos, dpp and vvl.
  • 基因功能參考文獻：
    1. Data indicate that the HMG-box of Capicua (CIC) does not bind DNA alone but instead requires a distant motif (referred to as C1) present at the C-terminus of all CIC proteins. PMID: 28278156
    2. Thus, Cic proteins employ distinct repressor mechanisms that are associated with discrete structural changes in the evolutionary history of this protein family. PMID: 25569482
    3. Capicua directly interacts with several corepressor-binding sites in the zerknullt ventral repression element. PMID: 25059278
    4. We propose that ERK-dependent relief of gene repression by Cic is a two-step process, in which fast reduction of repressor activity is followed by slower changes in nuclear localization and overall protein levels. PMID: 23733957
    5. [REVIEW] Capicua (CIC) is a key sensor of receptor tyrosine kinase (RTK) signaling in both Drosophila and mammals. PMID: 22526417
    6. Feedback regulation by bantam on Capicua provides a means to link signal propagation by the EGFR pathway to activity of the Hippo pathway and may play an important role in integration of these two pathways in growth control. PMID: 22445297
    7. The terminal and posterior systems function coordinately to alleviate transcriptional silencing by Capicua PMID: 15510215
    8. ATXN1 directly binds Capicua and modulates Capicua repressor activity in Drosophila and mammalian cells, and its loss decreases the steady-state level of Capicua. PMID: 17190598
    9. A MAPK docking site in Capicua is critical for its downregulation by Torso and EGFR RTK signaling. PMID: 17255944
    10. findings show Capicua restricts cell growth in imaginal discs, and its levels are, in turn, downregulated by Ras signaling; thus Cic is a key downstream component in the pathway by which Ras regulates growth in imaginal discs PMID: 17398096

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in the central region of embryos. Also expressed in ovarian follicle cells, the wing imaginal disks and the wing pouch.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG43122

    STRING: 7227.FBpp0293566

    UniGene: Dm.5727



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