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  4. Recombinant Drosophila melanogaster Protein sex-lethal (Sxl)

Recombinant Drosophila melanogaster Protein sex-lethal (Sxl)

  • 中文名稱：
    黑腹果蠅Sxl重組蛋白
  • 貨號：
    CSB-YP321682DLU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅Sxl重組蛋白
  • 貨號：
    CSB-EP321682DLU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅Sxl重組蛋白
  • 貨號：
    CSB-EP321682DLU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅Sxl重組蛋白
  • 貨號：
    CSB-BP321682DLU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅Sxl重組蛋白
  • 貨號：
    CSB-MP321682DLU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Sxl
  • Uniprot No.：
  • 別名：
    Sxl; Sx1; CG43770; Protein sex-lethal
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-354
  • 氨基酸序列
    MYGNNNPGSN NNNGGYPPYG YNNKSSGGRG FGMSHSLPSG MSRYAFSPQD TEFSFPSSSS RRGYNDFPGC GGSGGNGGSA NNLGGGNMCH LPPMASNNSL NNLCGLSLGS GGSDDLMNDP RASNTNLIVN YLPQDMTDRE LYALFRAIGP INTCRIMRDY KTGYSFGYAF VDFTSEMDSQ RAIKVLNGIT VRNKRLKVSY ARPGGESIKD TNLYVTNLPR TITDDQLDTI FGKYGSIVQK NILRDKLTGR PRGVAFVRYN KREEAQEAIS ALNNVIPEGG SQPLSVRLAE EHGKAKAAHF MSQMGVVPAN VPPPPPQPPA HMAAAFNMMH RGRSIKSQQR FQNSHPYFDA KKFI
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Sex determination switch protein which controls sexual development by sex-specific splicing. Regulates dosage compensation in females by suppressing hyperactivation of X-linked genes. Expression of the embryo-specific isoform is under the control of primary sex-determining signal, which depends on the ratio of X chromosomes relative to autosomes (X:A ratio). Expression occurs in 2X:2A cells, but not in X:2A cells. The X:A ratio seems to be signaled by the relative concentration of the X-linked transcription factors SIS-A and SIS-B. As a result, the embryo-specific product is expressed early only in female embryos and specifies female-adult specific splicing; in the male where it is not expressed, the default splicing gives rise to a truncated non-functional protein. The female-specific isoform specifies the splicing of its own transcript, thereby initiating a positive autoregulatory feedback loop leading to female development pathway. The female-specific isoform controls the sex-specific splicing of transformer (TRA); acts as a translational repressor for male-specific lethal-2 (MSL-2) and prevents male-less (MLE), MSL-1 and MSL-3 proteins from associating with the female X chromosome.
  • 基因功能參考文獻：
    1. Sxl is necessary for the cell-autonomous maintenance of germ cell female identity. PMID: 25758221
    2. During evolution, Sxl managed to usurp the role of tra as the master regulator of sex determination relatively quickly in Drosophila's insect ancestors. PMID: 24191002
    3. The maize 1-deoxy-D-xylulose 5-phosphate synthase genes display a particular tissue-specific expression that changes during plant development and in response to external signals. PMID: 21199890
    4. study demonstrates that, in Drosophila, the Sex lethal (Sxl) gene acts autonomously in primordial germ cells to induce female development PMID: 21737698
    5. Study shows that SXL controls a family of Drosophila mRNAs by regulation of upstream open reading frames (uORFs), and suggest that the underlying regulatory principle may apply more broadly to eukaryotic gene regulation PMID: 21663794
    6. Drosophila Sxl may appear functionally female specific not because it lost non-female-specific functions, but because those functions are nonessential in the laboratory PMID: 20837995
    7. sex-lethal is capable of direct physical interactions with chromosomes. This is consistent with the developmentally regulated nuclear localization of sex-lethal being important for oogenesis. PMID: 12000643
    8. This protein promotes the skipping of exon 3 from its own pre-mRNA. Two AG dinucleotides and an intervening Py-tract at the 3'end of intron 2 are important for autoregulation. PMID: 12015979
    9. Wolbachia restores fertility to Drosophila melanogaster mutant females prevented from making eggs by protein-coding lesions in Sex-lethal. PMID: 12097909
    10. SEX-LETHAL protein acts after splice site recognition, but before catalysis begins, in male exon skipping. PMID: 12490553
    11. Documents gutfeeling as a target and regulator of sex-lethal in early germ cells. PMID: 12645926
    12. This material binds to the 3'UTR of msl-2 mRNA and activates the translational repressor domain, thereby enabling it to recruit co-repressors in a specific fashion. PMID: 14532129
    13. hedgehog (Hh) promotes the entry of Sxl into the nucleus in the wing disc; In the anterior compartmentm Patched (Ptc) is required for this effect, revealing Ptc as a positive effector of Hh. PMID: 14597576
    14. The inhibition of male-specific lethal 2 (msl-2) mRNA translation by the RNA-binding protein sex-lethal (SXL) is an essential regulatory step for X-chromosome dosage compensation in Drosophila melanogaster PMID: 16452509
    15. Sxl transcript represents a novel target of Bruno-mediated translational repression required for cystoblast differentiation PMID: 17067567
    16. Results show that Sex-lethal, Patched and Smoothened co-immunoprecipitate and co-fractionate, suggesting a large complex of both membrane and cytoplasmic components of the Hedgehog pathway. PMID: 17284519
    17. The tra-mediated Sxl feedback in Drosophila may be a vestige of regulatory redundancy that facilitated the evolutionary transition from tra to Sxl as the master sex switch. PMID: 18845845

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  • 組織特異性：
    Expressed in somatic tissues, but not in the pole cells, which are the precursors of the germline.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG43770

    STRING: 7227.FBpp0303712

    UniGene: Dm.4502



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