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  4. Recombinant Drosophila melanogaster Protein fork head (fkh), partial

Recombinant Drosophila melanogaster Protein fork head (fkh), partial

  • 中文名稱：
    黑腹果蠅fkh重組蛋白
  • 貨號：
    CSB-YP318580DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅fkh重組蛋白
  • 貨號：
    CSB-EP318580DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅fkh重組蛋白
  • 貨號：
    CSB-EP318580DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅fkh重組蛋白
  • 貨號：
    CSB-BP318580DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅fkh重組蛋白
  • 貨號：
    CSB-MP318580DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    fkh
  • Uniprot No.：
  • 別名：
    fkh; CG10002Protein fork head
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Fkh promotes terminal as opposed to segmental development. In the absence of fkh, this developmental switch does not occur. The nuclear localization of the fkh protein suggest that fkh regulates the transcription of other, subordinate, genes.
  • 基因功能參考文獻：
    1. FKH in the gut in mediating anti-aging effects of reduced insulin/insulin growth factor. PMID: 29045833
    2. Fkh maintains the expression of stem/progenitor cell markers and is required for stem cell proliferation during intestinal homeostasis and regeneration.It prevents intestinal stem/progenitor cells from precocious differentiation into the enterocyte lineage, likely in cooperation with bHLH/Daughterless. Its loss suppresses the intestinal tumorigenesis caused by Notch pathway inactivation. PMID: 29108672
    3. controls activation of Dpt and Mtk PMID: 24842780
    4. Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin PMID: 21217822
    5. FKH represses trachealess (trh), a duct-specific gene initially expressed throughout the salivary gland primordium. PMID: 12798300
    6. Fkh cooperates with the salivary gland-specific bHLH protein Sage to directly regulate expression of PH4alphaSG2, as well as sage itself, and to indirectly regulate expression of PH4alphaSG1. PMID: 16914497
    7. Fkh plays a pivotal role in the normal control of developmental cell death. PMID: 17339378
    8. Mapping of potential trithorax-associated regulatory elements within the extended (9 kb) promoter region of the fork head gene (fkh) in the Drosophila melanogaster salivary gland cells was performed. PMID: 17990516

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  • 亞細胞定位：
    Nucleus.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG10002

    STRING: 7227.FBpp0303365

    UniGene: Dm.22561



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