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  4. Recombinant Drosophila melanogaster Probable UDP-glucose 4-epimerase (Gale)

Recombinant Drosophila melanogaster Probable UDP-glucose 4-epimerase (Gale)

  • 中文名稱：
    黑腹果蠅Gale重組蛋白
  • 貨號：
    CSB-YP894763DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅Gale重組蛋白
  • 貨號：
    CSB-EP894763DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅Gale重組蛋白
  • 貨號：
    CSB-EP894763DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅Gale重組蛋白
  • 貨號：
    CSB-BP894763DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅Gale重組蛋白
  • 貨號：
    CSB-MP894763DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Gale
  • Uniprot No.：
  • 別名：
    Gale; CG12030UDP-glucose 4-epimerase; EC 5.1.3.2; Galactowaldenase; UDP-N-acetylgalactosamine 4-epimerase; UDP-GalNAc 4-epimerase; UDP-N-acetylglucosamine 4-epimerase; UDP-GlcNAc 4-epimerase; EC 5.1.3.7; UDP-galactose 4-epimerase
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-350
  • 氨基酸序列
    MAPPTVLVTG GAGYIGSHTV LEMLNAGYNV ICVDNLCNAY SSGAKLPEAL SRVQEITGKK VNFYRVDITD REQVRSVFQE HKIDMVAHFA ALKAVGESCR IPLQYYHNNM TGTNVLLEAM ADNNVFKFVY SSSATVYGEP KFLPVTEEHP TGNCTSPYGK TKYFTEEILK DLCKSDKRWA VVSLRYFNPV GAHISGRIGE DPNGEPNNLM PYIAQVAVGR RPSLSVYGSD FPTHDGTGVR DYIHIVDLAE GHVKALDKLR NIAETGFFAY NLGTGVGYSV LDMVKAFEKA SGKKVNYTLV DRRSGDVATC YADATLADKK LGWKAERGID KMCEDTWRWQ SQNPNGYANK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
  • 基因功能參考文獻：
    1. Our results demonstrate that both UDP-gal and UDP-galNAc activities of dGALE are required for Drosophila survival, although distinct roles for each activity can be seen in specific windows of developmental time or in response to a galactose challenge. PMID: 22654673
    2. Drosophila with partial GALE loss survive in the absence of galactose but succumb in development if exposed to dietary galactose. PMID: 20519568
  • 蛋白家族：
    NAD(P)-dependent epimerase/dehydratase family
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG12030

    STRING: 7227.FBpp0072455

    UniGene: Dm.4155



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