在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Drosophila melanogaster Probable RNA-binding protein orb2 (orb2), partial

Recombinant Drosophila melanogaster Probable RNA-binding protein orb2 (orb2), partial

  • 中文名稱(chēng)：
    黑腹果蠅orb2重組蛋白
  • 貨號(hào)：
    CSB-YP893322DLU
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱(chēng)：
    黑腹果蠅orb2重組蛋白
  • 貨號(hào)：
    CSB-EP893322DLU
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱(chēng)：
    黑腹果蠅orb2重組蛋白
  • 貨號(hào)：
    CSB-EP893322DLU-B
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱(chēng)：
    黑腹果蠅orb2重組蛋白
  • 貨號(hào)：
    CSB-BP893322DLU
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱(chēng)：
    黑腹果蠅orb2重組蛋白
  • 貨號(hào)：
    CSB-MP893322DLU
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    orb2
  • Uniprot No.：
  • 別名：
    orb2; CG43782; Translational regulator orb2
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    RNA-binding protein involved in translational regulation and required for long-term memory. Required in mushroom body gamma neurons for long-term memory in male courtship. Binds to mRNA 3'-UTRs. In its monomeric form, acts as a translational repressor of genes involved in neuronal growth, synapse formation and protein turnover. In its amyloid-like oligomeric form, acts as a translational activator. The monomeric form reduces poly(A) tail length and destabilizes mRNA while the oligomeric form protects and elongates the poly(A) tail and stabilizes mRNA. Involved in asymmetric cell division in the central nervous system. Plays a role in synapse formation and morphology at neuromuscular junctions by modulating the translation of the tumor suppressor brat. Required for the progression of spermatogenesis through meiosis and for sperm differentiation. During sperm differentiation, required to asymmetrically localize and activate the translation of protein kinase aPKC mRNAs which is necessary for spermatid cyst polarization. Also required during spermatid cyst polarization for localization and translation of its own mRNA.; Required for initial memory acquisition. Following subsequent late dopaminergic pathway activation, recruits isoform B into a complex to activate translation of CaMKII which is required for long-term memory consolidation.
  • 基因功能參考文獻(xiàn)：
    1. We present here evidences of a novel genetic mechanism to regulate synapse fine tuning during development and propose an equilibrium between Orb2 conformational state and nervous system formation. PMID: 29105522
    2. The N-terminus of Orb2A not only promotes the formation of fibrils, but also forms the fibril core. PMID: 27922050
    3. Data confirm the original hypothesis that the glutamine, histidine-rich (Q/H-rich) domain of Orb2 can bind to transition metals via its His residues. Hence, the Q/H rich domain behaves like other H-rich domains, most of which were shown to be metal binding domains. PMID: 28763009
    4. Study showed that the N-terminus specific to Orb2A can bind to lipid membranes; binding occurs preferentially to curved membranes and requires the membranes to be negatively charged. When binding to lipid membranes, the N-terminus of Orb2A undergoes a transition from a dynamic, intrinsically disordered state to a less dynamic alpha-helix. This lipid membrane interaction can prevent the N-terminus from forming amyloid f... PMID: 28700922
    5. Authors posit that pasilla-mediated processing of unspliced Orb2A mRNA integrates experience and internal state to control Orb2A protein abundance and long-term memory formation. PMID: 28525754
    6. rapidly forms amyloids and its toxic intermediates are extremely transient PMID: 26812143
    7. Data support a model in which monomeric Orb2 keeps target mRNA in a translationally dormant state and experience-dependent conversion to the amyloidogenic state activates translation, resulting in persistent alteration of synaptic activity and stabilization of memory. PMID: 26638074
    8. we present evidence that, during learning, the translational regulator Orb2A tags specific synapses of mushroom body neurons for later consolidation. Consolidation involves the subsequent recruitment of Orb2B and the activity-dependent synthesis of CaMKII PMID: 26095367
    9. analysis of a partial loss of function orb2 mutant suggests that the orb2 differentiation phenotypes are independent of the earlier arrest in meiosis PMID: 23209437
    10. This study demonistrated that Drosophila CPEB Orb2A mediates memory independent of Its RNA-binding domain. PMID: 23083740

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Perikaryon. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Cytoplasm. Cytoplasm, perinuclear region.; [Isoform A]: Cell junction, synapse.; [Isoform B]: Perikaryon. Cell projection, axon. Cell junction, synapse.
  • 組織特異性：
    Broadly expressed throughout the nervous system of embryo, larva and adult including the ventral nerve cord and brain (at protein level). In early embryos, deposited maternally and distributed uniformly throughout the embryo until the extended germband st
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: dme:Dmel_CG43782

    STRING: 7227.FBpp0303905

    UniGene: Dm.4024



主站蜘蛛池模板： 在线视频夫妻内射| 特级做a爰片毛片免费看无码| 国产精品情侣呻吟对白视频| 国产高清午夜人成在线观看| 无码中文字幕va精品影院| 一本无码人妻在中文字幕| 精品一区二区av天堂| 亚洲成a∨人片在线观看不卡| 全部孕妇毛片| 日韩加勒比一本无码精品| 最近更新中文字幕免费大全| 51国偷自产一区二区三区| 少妇无码av无码专区线| 欧美中文亚洲v在线| 国产青榴视频在线观看| 欧美色综合天天久久综合精品| 欧美极品video粗暴| 亚洲成亚洲成网| av免费网站在线观看| 国产成人无码aⅴ片在线观看| 欧洲美女黑人粗性暴交视频| 天堂网www最新版官网| 无码人妻aⅴ一区二区三区69岛| 久久久久欧美精品| 国产精品a国产精品a手机版| 鲁鲁网亚洲站内射污| 精品久久国产字幕高潮| 成人区精品一区二区不卡| 色五月丁香五月综合五月| 中文字幕人妻色偷偷久久| 亚洲国产另类久久久精品黑人| 国产av亚洲精品ai换脸电影| 欧美亚洲国产片在线播放| 中文在线а天堂中文在线新版| av中文无码乱人伦在线观看| 国产av天堂亚洲国产av麻豆 | 无码夜色一区二区三区| 拍国产乱人伦偷精品视频| 图片区小说区亚洲欧美自拍| 又大又粗弄得我出好多水| 亚洲日韩成人性av网站|