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  4. Recombinant Drosophila melanogaster Pro-corazonin (Crz)

Recombinant Drosophila melanogaster Pro-corazonin (Crz)

  • 中文名稱：
    Recombinant Drosophila melanogaster Pro-corazonin(Crz)
  • 貨號：
    CSB-YP630616DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Pro-corazonin(Crz)
  • 貨號：
    CSB-EP630616DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Pro-corazonin(Crz)
  • 貨號：
    CSB-EP630616DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Pro-corazonin(Crz)
  • 貨號：
    CSB-BP630616DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Pro-corazonin(Crz)
  • 貨號：
    CSB-MP630616DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Crz
  • Uniprot No.：
  • 別名：
    Crz; CG3302Pro-corazonin; Crz; Dm-Crz) [Cleaved into: Corazonin; Corazonin precursor-related peptide; CPRP; Crz-associated peptide)]
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    20-154
  • 氨基酸序列
    Q TFQYSRGWTN GKRSFNAASP LLANGHLHRA SELGLTDLYD LQDWSSDRRL ERCLSQLQRS LIARNCVPGS DFNANRVDPD PENSAHPRLS NSNGENVLYS SANIPNRHRQ SNELLEELSA AGGASAEPNV FGKH
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat. Clock (Clk) and cycle (cyc) proteins negatively regulate Crz transcription in a cell-specific manner.
  • 基因功能參考文獻：
    1. Loss of Atg16 delays the alcohol-induced sedation response via regulation of Corazonin neuropeptide production in Drosophila. PMID: 27708416
    2. Results show that the Crz action triggers transcriptional changes in the adipocytes that include stress genes and one gene involved in metabolism. PMID: 27810969
    3. Data show that altered corazonin neuron physiology leads to fundamental differences in locomotor activity, and these effects were also sex-dependent. PMID: 20161767
    4. provide evidence showing that a group of neurons (vCrz) that express neuropeptide Corazonin (Crz) gene in the ventral nerve cord of the larval central nervous system undergo programmed death within 6 hours of the onset of metamorphosis PMID: 16672345
    5. The tissue-, stage-, and sex-specific expression of Crz and the association of Crz with the function of the retrocerebral complex suggest diverse roles for this neuropeptide in Drosophila. PMID: 18087727
    6. We show that the 504-bp 5' upstream sequence is the shortest promoter directing reporter activities in all Drosophila Corazonin neurons. PMID: 18181151

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  • 亞細胞定位：
    [Corazonin]: Secreted.; [Corazonin precursor-related peptide]: Secreted.
  • 蛋白家族：
    Corazonin family
  • 組織特異性：
    From late embryo to larva, expression is consistently detected in three neuronal groups: dorso-lateral neurons (DL), dorso-medial neurons (DM), and neurons in the ventral nerve cord (vCrz). Both the vCrz and DM groups die via programmed cell death during
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG3302

    STRING: 7227.FBpp0082386

    UniGene: Dm.2429



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