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  4. Recombinant Drosophila melanogaster Polycomb protein Scm (Scm), partial

Recombinant Drosophila melanogaster Polycomb protein Scm (Scm), partial

  • 中文名稱：
    黑腹果蠅Scm重組蛋白
  • 貨號：
    CSB-YP895612DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅Scm重組蛋白
  • 貨號：
    CSB-EP895612DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅Scm重組蛋白
  • 貨號：
    CSB-EP895612DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅Scm重組蛋白
  • 貨號：
    CSB-BP895612DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅Scm重組蛋白
  • 貨號：
    CSB-MP895612DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Scm
  • Uniprot No.：
  • 別名：
    Scm; CG9495; Polycomb protein Scm; Sex comb on midleg protein
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility.
  • 基因功能參考文獻：
    1. loss-of-function mutations in Scm result in non-autonomous tissue overgrowth in Drosophila, and determine that Scm is essential for ommatidium development and important for cell survival in Drosophila PMID: 25772304
    2. Scm coordinates PcG complexes and polymerizes to produce broad domains of PcG silencing PMID: 26063573
    3. SUMO negatively regulates Scm function by impeding its recruitment to the Ubx major PRE. PMID: 21278366
    4. Data show that Sex Comb on Midleg (SCM) associates with a Polycomb response element upstream of the Ubx gene which also binds PRC1, PRC2, and the DNA-binding PcG protein Pleiohomeotic. PMID: 20351181
    5. SCM interacts and functions with Polycomb repressive complex 1 in gene silencing. PMID: 15280237
    6. polymeric Scm complexes could extend beyond the local domains of polymeric Ph complexes on chromatin, possibly playing a role in long range repression PMID: 15905166
    7. Data show that the MBT domain of Sex comb on midleg and its methyl-lysine-binding activity are required for repression of Hox genes. PMID: 17932512
    8. Testing the role of this structure in male mating success in Drosophila melanogaster, the sex comb was removed by expressing the female-specific isoform of the sex determination gene transformer in the tarsal segments of male legs. PMID: 18213513

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    SCM family
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG9495

    STRING: 7227.FBpp0081580

    UniGene: Dm.6241



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