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  4. Recombinant Drosophila melanogaster Poly [ADP-ribose] polymerase (Parp), partial

Recombinant Drosophila melanogaster Poly [ADP-ribose] polymerase (Parp), partial

  • 中文名稱：
    黑腹果蠅Parp重組蛋白
  • 貨號：
    CSB-YP330499DLU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅Parp重組蛋白
  • 貨號：
    CSB-EP330499DLU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅Parp重組蛋白
  • 貨號：
    CSB-EP330499DLU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅Parp重組蛋白
  • 貨號：
    CSB-BP330499DLU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅Parp重組蛋白
  • 貨號：
    CSB-MP330499DLU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Parp
  • Uniprot No.：
  • 別名：
    Parp; CG40411; Poly [ADP-ribose] polymerase; PARP; EC 2.4.2.30; NAD(+) ADP-ribosyltransferase; ADPRT; Poly[ADP-ribose] synthase; Protein ADP-ribosyltransferase Parp; EC 2.4.2.-
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of CG1218/HPF1. Following interaction with CG1218/HPF1, catalyzes serine ADP-ribosylation of target proteins; CG1218/HPF1 conferring serine specificity by completing the Parp active site.; Plays a fundamental role in organizing chromatin on a global scale. Autoregulates Parp transcription by influencing the chromatin structure of its heterochromatic environment.
  • 基因功能參考文獻：
    1. The results demonstrate that PARylation process in Drosophila is tightly regulated in the context of strands-breaks repair; PARP is essential during the maintenance of DNA integrity, but dispensable in the DNA repair process. PMID: 27793508
    2. A mutation of Parp also increases NAD+ levels; although, this was only observed in parkin mutant flies and not in the heterozygous Parp mutants, possibly owing to an increased PARP activity in the parkin mutants. PMID: 27031963
    3. Based on these findings, we propose a model that explains how PARP1 activity impacts nucleolar functions and, consequently, ribosomal biogenesis PMID: 22242017
    4. PARP is associated with the 5' end of Hsp70, and its enzymatic activity is rapidly induced by heat shock leading to nucleosome loss. PMID: 22178397
    5. Activation of PARP-1 overexpression in the imago results in extension of the lifespan in females and males. The lifespan increase in females with PARP-1 conditional overexpression was accompanied by decrease of fertility. PMID: 22184968
    6. inhibits transcription by contributing to the condensation of chromatin, which creates a barrier against gene transcription PMID: 20591646
    7. demonstrate that this alteration specifically excludes PARP1 protein from heterochromatin and makes PARP1 unable to maintain repression of retrotransposable elements. PMID: 20371698
    8. PARP-e autoregulates Parp transcription PMID: 12183365
    9. propose that chromosomal PARP molecules become activated by developmental or environmental cues and strip nearby chromatin proteins off DNA to generate a puff PMID: 12543974
    10. PARP1 is required for protein targeting to Cajal body. PMID: 19229318

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  • 亞細胞定位：
    Nucleus. Chromosome. Nucleus, nucleolus.
  • 組織特異性：
    Expressed in adult female oocytes, anal plates of stage 12 embryos and in cells around the central nervous system in later embryos.
  • 數(shù)據(jù)庫鏈接：

    KEGG: dme:Dmel_CG40411

    STRING: 7227.FBpp0112608

    UniGene: Dm.7847



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