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  4. Recombinant Drosophila melanogaster Peptidoglycan-recognition protein SD (PGRP-SD)

Recombinant Drosophila melanogaster Peptidoglycan-recognition protein SD (PGRP-SD)

  • 中文名稱：
    黑腹果蠅PGRP-SD重組蛋白
  • 貨號：
    CSB-YP893320DLU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅PGRP-SD重組蛋白
  • 貨號：
    CSB-EP893320DLU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅PGRP-SD重組蛋白
  • 貨號：
    CSB-EP893320DLU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅PGRP-SD重組蛋白
  • 貨號：
    CSB-BP893320DLU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅PGRP-SD重組蛋白
  • 貨號：
    CSB-MP893320DLU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PGRP-SD
  • Uniprot No.：
  • 別名：
    PGRP-SD; CG7496; Peptidoglycan-recognition protein SD
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    19-186
  • 氨基酸序列
    EV PIVTRAEWNA KPPNGAIDSM ETPLPRAVIA HTAGGACADD VTCSQHMQNL QNFQMSKQKF SDIGYHYLIG GNGKVYEGRS PSQRGAFAGP NNDGSLGIAF IGNFEERAPN KEALDAAKEL LEQAVKQAQL VEGYKLLGHR QVSATKSPGE ALYALIQQWP NWSEEM
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway. Has no activity against on Gram-negative bacteria and fungi. Shows some partial redundancy with PRPGP-SA in Gram-positive bacteria recognition. May act by activating the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway. Recognizes S.aureus PGN.
  • 基因功能參考文獻：
    1. These data reveal that Drosophila PGRP-SD functions as an extracellular receptor similar to mammalian CD14 PMID: 27851910
    2. crystal structure of PGRP-SD at 1.5A resolution; findings suggest a diaminopimelic acid (DAP) specificity for PGRP-SD; hypothesis is that role of PGRP-SD is recognition of DAP-type PGNs responsible for activation of Toll pathway by Gram-negative bacteria PMID: 18304640
    3. interplay between the binding affinities of different PGRPs provides sufficient flexibility for the recognition of the highly diverse Gram-positive peptidoglycan PMID: 18697931
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    N-acetylmuramoyl-L-alanine amidase 2 family
  • 組織特異性：
    In larvae, it is mainly expressed in fat body. Also expressed in uninduced hemocytes and mbn-2 cells.
  • 數(shù)據(jù)庫鏈接：

    KEGG: dme:Dmel_CG7496

    STRING: 7227.FBpp0076519

    UniGene: Dm.33934



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