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  4. Recombinant Drosophila melanogaster Peptidoglycan-recognition protein SA (PGRP-SA)

Recombinant Drosophila melanogaster Peptidoglycan-recognition protein SA (PGRP-SA)

  • 中文名稱：
    黑腹果蠅PGRP-SA重組蛋白
  • 貨號：
    CSB-YP895215DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅PGRP-SA重組蛋白
  • 貨號：
    CSB-EP895215DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅PGRP-SA重組蛋白
  • 貨號：
    CSB-EP895215DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅PGRP-SA重組蛋白
  • 貨號：
    CSB-BP895215DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅PGRP-SA重組蛋白
  • 貨號：
    CSB-MP895215DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PGRP-SA
  • Uniprot No.：
  • 別名：
    PGRP-SA; seml; CG11709; Peptidoglycan-recognition protein SA; EC 3.4.17.13; Protein semmelweis
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    27-203
  • 氨基酸序列
    GKSR QRSPANCPTI KLKRQWGGKP SLGLHYQVRP IRYVVIHHTV TGECSGLLKC AEILQNMQAY HQNELDFNDI SYNFLIGNDG IVYEGTGWGL RGAHTYGYNA IGTGIAFIGN FVDKLPSDAA LQAAKDLLAC GVQQGELSED YALIAGSQVI STQSPGLTLY NEIQEWPHWL SNP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway upstream of spz activating enzyme SPE. Has no activity against Gram-negative bacteria and fungi. Shows some partial redundancy with PRPGP-SD in Gram-positive bacteria recognition. May act by forming a complex with GNBP1 that activates the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway. Binds to diaminopimelic acid-type tetrapeptide PGN (DAP-type PGN) and lysine-type PGN (Lys-type PGN). Has some L,D-carboxypeptidase activity for DAP-type PGN, which are specific to prokaryotes, but not for Lys-type PGN.
  • 基因功能參考文獻：
    1. Wall teichoic acids of Staphylococcus aureus limit recognition by the drosophila peptidoglycan recognition protein-SA to promote pathogenicity. PMID: 22144903
    2. results demonstrate that GNBP1 and PGRP-SA can jointly activate the Toll pathway PMID: 14684822
    3. PGRP-SA contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity PMID: 15361936
    4. GNBP1 presents a processed form of peptidoglycan for sensing by PGRP-SA and that a tripartite interaction between these proteins and peptidoglycan is essential for downstream signaling. PMID: 17024181
  • 亞細胞定位：
    Secreted. Note=Secreted in hemolymph.
  • 蛋白家族：
    N-acetylmuramoyl-L-alanine amidase 2 family
  • 組織特異性：
    In larvae, it is expressed in fat body. Also expressed in uninduced hemocytes and mbn-2 cells.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG11709

    STRING: 7227.FBpp0073358

    UniGene: Dm.14186



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