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  4. Recombinant Drosophila melanogaster LIM domain kinase 1 (LIMK1), partial

Recombinant Drosophila melanogaster LIM domain kinase 1 (LIMK1), partial

  • 中文名稱：
    黑腹果蠅LIMK1重組蛋白
  • 貨號：
    CSB-YP012952DLU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅LIMK1重組蛋白
  • 貨號：
    CSB-EP012952DLU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅LIMK1重組蛋白
  • 貨號：
    CSB-EP012952DLU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅LIMK1重組蛋白
  • 貨號：
    CSB-BP012952DLU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅LIMK1重組蛋白
  • 貨號：
    CSB-MP012952DLU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    LIMK1; LIMK; CG1848LIM domain kinase 1; LIMK-1; EC 2.7.11.1; dLIMK
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor tsr/cofilin, thereby stabilizing the actin cytoskeleton. Modulation of actin cytoskeleton dynamics may be essential for imaginal disk morphogenesis and axon guidance.
  • 基因功能參考文獻：
    1. Genetic analysis in Drosophila midgut revealed a conserved role for dLIMK in constraining gastrointestinal stem cell proliferation. PMID: 23585469
    2. functional connections at the behavioral level (learning/memory) depending on the GDNF and LIMK1 brain expression and HSPs transduction that might provide targets for complex approaches for the neurodegenerative diseases treatment. PMID: 23401971
    3. Rac may signal through Pak and LIMK to result in uniform phosphorylation of cofilin in all the outer border cells. PMID: 21205790
    4. LIMK1 localizes near synaptic microtubules, highlighting a novel requirement for LIMK1 during synapse stabilization PMID: 16129399
    5. Limk is a critical regulator of cofilin function and synapse development, and a downstream effector of p21-activated kinase (Pak) in vivo. PMID: 16529736
    6. The higher resistance of characterictics of behavior and communicative sound signals to heat shock is in agreement with the fact that the extremely high LIMK1 and P-cofilin concentrations in cells go down to normal values after heat shock. PMID: 19435260

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  • 亞細胞定位：
    Cytoplasm. Cleavage furrow. Midbody. Note=Localizes to the cleavage furrow and the midbody at cytokinesis.
  • 蛋白家族：
    Protein kinase superfamily, TKL Ser/Thr protein kinase family
  • 組織特異性：
    Expressed throughout the imaginal disks of the eye, leg and wing.
  • 數(shù)據(jù)庫鏈接：

    KEGG: dme:Dmel_CG1848

    STRING: 7227.FBpp0073493

    UniGene: Dm.3774



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