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  4. Recombinant Drosophila melanogaster H/ACA ribonucleoprotein complex subunit 4 (Nop60B), partial

Recombinant Drosophila melanogaster H/ACA ribonucleoprotein complex subunit 4 (Nop60B), partial

  • 中文名稱：
    黑腹果蠅Nop60B重組蛋白
  • 貨號：
    CSB-YP006919DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅Nop60B重組蛋白
  • 貨號：
    CSB-EP006919DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅Nop60B重組蛋白
  • 貨號：
    CSB-EP006919DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅Nop60B重組蛋白
  • 貨號：
    CSB-BP006919DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅Nop60B重組蛋白
  • 貨號：
    CSB-MP006919DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Nop60B
  • Uniprot No.：
  • 別名：
    Nop60B; mfl; CG3333; H/ACA ribonucleoprotein complex subunit 4; EC 5.4.99.-; Nucleolar protein AT band 60B; Protein minifly
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. Required for maintenance of the germline stem cell lineage during spermatogenesis.
  • 基因功能參考文獻：
    1. Study demonstrates that either ubiquitous or escargot-driven dyskerin depletion specifically abolishes the formation of the intestinal imaginal islands, the transient stem cell niche, without any apparent effect on the other midgut cell types. PMID: 28337032
    2. Pseudouridine synthase (diskerin,Mfl)depletion also causes disruption of adherens cell junctions and ectopic induction of JNK (c-Jun N-terminal kinase) and Mmp1 (matrix metalloproteinase-1) activity, leading to a significant epithelial reorganization PMID: 25811802
    3. Mutations in Nop60B, the Drosophila homolog of human dyskeratosis congenita 1, affect the maintenance of the germ-line stem cell lineage during spermatogenesis. PMID: 12645924
    4. results expand repertoire of coding/non-coding transcripts derived from the gene encoding Drosophila pseudouridine synthase It exhibits complex interlaced organization. PMID: 17328797
  • 亞細胞定位：
    Nucleus, nucleolus.
  • 蛋白家族：
    Pseudouridine synthase TruB family
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG3333

    STRING: 7227.FBpp0099583

    UniGene: Dm.1944



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