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  4. Recombinant Drosophila melanogaster GTP-binding protein Rheb homolog (Rheb)

Recombinant Drosophila melanogaster GTP-binding protein Rheb homolog (Rheb)

  • 中文名稱(chēng)：
    黑腹果蠅Rheb重組蛋白
  • 貨號(hào)：
    CSB-YP895638DLU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱(chēng)：
    黑腹果蠅Rheb重組蛋白
  • 貨號(hào)：
    CSB-EP895638DLU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱(chēng)：
    黑腹果蠅Rheb重組蛋白
  • 貨號(hào)：
    CSB-EP895638DLU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱(chēng)：
    黑腹果蠅Rheb重組蛋白
  • 貨號(hào)：
    CSB-BP895638DLU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱(chēng)：
    黑腹果蠅Rheb重組蛋白
  • 貨號(hào)：
    CSB-MP895638DLU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Rheb; CG1081; GTP-binding protein Rheb homolog
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-179
  • 氨基酸序列
    MPTKERHIAM MGYRSVGKSS LCIQFVEGQF VDSYDPTIEN TFTKIERVKS QDYIVKLIDT AGQDEYSIFP VQYSMDYHGY VLVYSITSQK SFEVVKIIYE KLLDVMGKKY VPVVLVGNKI DLHQERTVST EEGKKLAESW RAAFLETSAK QNESVGDIFH QLLILIENEN GNPQEKSGC
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Binds GTP and exhibits intrinsic GTPase activity. Activates the protein kinase activity of TORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K through activation of TORC1 signaling. May also have a role in activating TORC2 signaling.
  • 基因功能參考文獻(xiàn)：
    1. Rheb overexpression in the central brain neurons of flies causes not only morphological phenotypes, but behavioral and aging phenotypes that may mirror symptoms of tuberous sclerosis complex PMID: 23028662
    2. Rheb promotes cell growth as a component of the insulin/TOR signaling network. PMID: 12766776
    3. Rheb is a direct target of the tuberous sclerosis suppressor proteins. PMID: 12771962
    4. dRheb is required for both cell growth (increase in mass) and cell cycle progression PMID: 12893813
    5. Rheb-TOR signaling controls S2 cell growth by promoting ribosome production and protein synthesis, not by direct effects on the import of amino acids or glucose. PMID: 17371599

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  • 亞細(xì)胞定位：
    Endomembrane system; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Rheb family
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: dme:Dmel_CG1081

    STRING: 7227.FBpp0078342

    UniGene: Dm.11577



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