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  4. Recombinant Drosophila melanogaster Frequenin-1 (Frq1)

Recombinant Drosophila melanogaster Frequenin-1 (Frq1)

  • 中文名稱：
    黑腹果蠅Frq1重組蛋白
  • 貨號：
    CSB-YP339793DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅Frq1重組蛋白
  • 貨號：
    CSB-EP339793DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅Frq1重組蛋白
  • 貨號：
    CSB-EP339793DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅Frq1重組蛋白
  • 貨號：
    CSB-BP339793DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅Frq1重組蛋白
  • 貨號：
    CSB-MP339793DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Frq1
  • Uniprot No.：
  • 別名：
    Frq1; Frq; CG5744Frequenin-1; d-FRQ
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-187
  • 氨基酸序列
    GKKSSKLKQ DTIDRLTTDT YFTEKEIRQW HKGFLKDCPN GLLTEQGFIK IYKQFFPQGD PSKFASLVFR VFDENNDGSI EFEEFIRALS VTSKGNLDEK LQWAFRLYDV DNDGYITREE MYNIVDAIYQ MVGQQPQSED ENTPQKRVDK IFDQMDKNHD GKLTLEEFRE GSKADPRIVQ ALSLGGG
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Ca(2+)-dependent modulation of synaptic efficacy.
  • 基因功能參考文獻：
    1. [review] Stimulation protocols, sources of calcium and expression patterns (presynaptic vs postsynaptic) of Frq may result in the activation of various protein targets, leading to different synaptic effects. PMID: 22396213
    2. Frq modulates Ca(2+) entry through a functional interaction with the alpha(1) voltage-gated Ca(2+)-channel subunit; this interaction regulates neurotransmission and nerve-terminal growth. PMID: 19861494
    3. Synonymous substitutions have been prevalent in the evolution of the coding region of frq1 and frq2, indicating the presence of strong functional constraints following gene duplication. PMID: 20170488
    4. We conclude that Frqs have two distinct functions: one in neurotransmission, regulating the probability of release per synapse, and another in axonal growth and bouton formation. PMID: 17970740
  • 亞細胞定位：
    Membrane; Lipid-anchor.
  • 蛋白家族：
    Recoverin family
  • 組織特異性：
    Enriched in synapses, such as the motor nerve endings at neuromuscular junctions.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG5744

    STRING: 7227.FBpp0074319

    UniGene: Dm.35315



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