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  4. Recombinant Drosophila melanogaster F-box/WD repeat-containing protein 7 (ago), partial

Recombinant Drosophila melanogaster F-box/WD repeat-containing protein 7 (ago), partial

  • 中文名稱：
    Recombinant Drosophila melanogaster F-box/WD repeat-containing protein 7(ago) ,partial
  • 貨號：
    CSB-YP895217DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster F-box/WD repeat-containing protein 7(ago) ,partial
  • 貨號：
    CSB-EP895217DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster F-box/WD repeat-containing protein 7(ago) ,partial
  • 貨號：
    CSB-EP895217DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster F-box/WD repeat-containing protein 7(ago) ,partial
  • 貨號：
    CSB-BP895217DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster F-box/WD repeat-containing protein 7(ago) ,partial
  • 貨號：
    CSB-MP895217DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ago
  • Uniprot No.：
  • 別名：
    ago; CG15010; F-box/WD repeat-containing protein 7; F-box and WD-40 domain-containing protein 7; Protein archipelago
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. In the wing and eye, negatively regulates cell growth and proliferation by mediating the degradation of Myc and cyclin E, respectively. Required for endocycles, but not mitosis in follicle cell epithelium.
  • 基因功能參考文獻：
    1. these findings identify Ago as a required element of a circuit that suppresses the tracheogenic activity of larval muscle cells by antagonizing the Sima-mediated transcriptional response to hypoxia. PMID: 23459416
    2. Ago loss induces hyperplasia of some organs but paradoxically reduces the size of the adult eye. PMID: 19733076
    3. archipelago is an important inhibitor of Drosophila Myc in developing tissues, and can regulate Cyclin E levels and Notch activity. PMID: 15182669
    4. novel function for the ago ubiquitin-ligase in tracheal morphogenesis via Trh and its target breathless, and suggest that ago has distinct functions in mitotic and post-mitotic cells that influence its role in development and disease PMID: 17976568
  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in follicle cell epithelium and imaginal disks, particularly in the morphogenetic furrow.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG15010

    STRING: 7227.FBpp0073101

    UniGene: Dm.2559



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