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  4. Recombinant Drosophila melanogaster Dystrophin, isoform E (Dys), partial

Recombinant Drosophila melanogaster Dystrophin, isoform E (Dys), partial

  • 中文名稱：
    黑腹果蠅Dys重組蛋白
  • 貨號：
    CSB-YP773771DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅Dys重組蛋白
  • 貨號：
    CSB-EP773771DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅Dys重組蛋白
  • 貨號：
    CSB-EP773771DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅Dys重組蛋白
  • 貨號：
    CSB-BP773771DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅Dys重組蛋白
  • 貨號：
    CSB-MP773771DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Dys
  • Uniprot No.：
  • 別名：
    Dys; det; CG34157Dystrophin; isoform E; Protein detached
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Specifically required for survival and integrity of the larval musculature: the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. May play a role in anchoring the cytoskeleton to the plasma membrane.
  • 基因功能參考文獻：
    1. Dys protein regulates tarsal joint formation in response to Notch activity during Drosophila leg development. PMID: 25329825
    2. The findings suggest that the signaling functions of Dystrophin protein are able to ameliorate dilated cardiomyopathy, and thus might help to improve heart muscle function in micro-Dystrophin-based gene therapy approaches. PMID: 24231130
    3. 3 5' promoters and 3 internal promoters regulate expression of 3 full-length and 3 truncated products, respectively. The existence of this complex gene structure in such evolutionary remote organisms suggests that it has diverse important functions PMID: 16198353
    4. Lack of the large dystrophin isoforms in the postsynaptic muscle cell leads to elevated evoked neurotransmitter release from presynaptic terminals. PMID: 16399704
    5. Our results indicate the existence of at least two possibly separate roles of dystrophin in muscle, maintaining synaptic homeostasis and preserving the structural stability of the muscle. PMID: 17543506
    6. The det locus encodes Drosophila dys, which acts with other components of the DAPC to influence intercellular signalling in developing wing veins. PMID: 18093579
    7. RNAi-mediated knockdown in the mesoderm shortens lifespan. Deletion of the large isoforms increases the heart rate by widening the cardiac tube and lowering fractional shortening, a phenotype reminiscent of dilated cardiomyopathy PMID: 18221418
    8. Possibility that Dp186 modulates other non-Gbb/Wit-dependent retrograde signaling pathways required to maintain normal synaptic physiology. PMID: 18463264

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  • 亞細胞定位：
    Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
  • 組織特異性：
    Expressed predominantly in all body wall muscle fibers during embryogenesis and in third instar larvae. Expression is also seen in the embryonic and larval ventral midline and larval brain.
  • 數據庫鏈接：

    UniGene: Dm.16710



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