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  4. Recombinant Drosophila melanogaster Dynein light chain 1, cytoplasmic (ctp)

Recombinant Drosophila melanogaster Dynein light chain 1, cytoplasmic (ctp)

  • 中文名稱：
    Recombinant Drosophila melanogaster Dynein light chain 1, cytoplasmic(ctp)
  • 貨號：
    CSB-YP637582DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Dynein light chain 1, cytoplasmic(ctp)
  • 貨號：
    CSB-EP637582DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Dynein light chain 1, cytoplasmic(ctp)
  • 貨號：
    CSB-EP637582DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Dynein light chain 1, cytoplasmic(ctp)
  • 貨號：
    CSB-BP637582DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Dynein light chain 1, cytoplasmic(ctp)
  • 貨號：
    CSB-MP637582DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ctp
  • Uniprot No.：
  • 別名：
    ctp; Cdlc1; ddlc1; CG6998Dynein light chain 1; cytoplasmic; 8 kDa dynein light chain; Cut up protein
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-89
  • 氨基酸序列
    MSDRKAVIKN ADMSEEMQQD AVDCATQALE KYNIEKDIAA YIKKEFDKKY NPTWHCIVGR NFGSYVTHET RHFIYFYLGQ VAILLFKSG
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as a non-catalytic accessory component of a dynein complex.
  • 基因功能參考文獻：
    1. Genetic and biochemical analyses reveals that the Drosophila homolog of the LC8 dynein light chains (mammalian DYNLL1 and DYNLL2), called Cut up, binds proteasomes and functions specifically during their transport. These data support the model that Cut up functions to specify the dynein-mediated transport of neuronal proteasomes. PMID: 28808087
    2. Data suggest that Ctp may interact with a Hippo pathway protein(s) to exert inverse transcriptional effects on Yorkie-target genes. PMID: 26972460
    3. Size exclusion chromatography coupled with multiangle static light scattering demonstrates that LC8 dimers bind Ana2M sites and induce Ana2 tetramerization, yielding an Ana2M4-LC88 complex. PMID: 24920673
    4. Dynein light chain 1 functions in somatic cyst cells to regulate spermatogonial divisions in Drosophila PMID: 22355688
    5. these findings reveal that the centrosomal proteins Ana2 and Ctp regulate Mud function to orient the mitotic spindle during neuroblasts asymmetric division. PMID: 21920316
    6. LC8 binding promotes IC self-association of helix 1 from each of two IC chains, whereas LC7 binding reverses self-association by incorporating the same residues into two symmetrical, but distant, helices of the LC7-IC complex PMID: 20974845
    7. Data propose bicoid mRNA localization was done by Swallow indirectly organizing the cytoskeleton, whereas Staufen plays a direct role in dynein-dependent bicoid mRNA transport. PMID: 20023172
    8. Interactions of cytoplasmic dynein light chains Tctex-1 and LC8 with the intermediate chain IC74 PMID: 11914076
    9. DDLC1 interacts with the Dynein-Dynactin complex at the distal ends of spermatids to maintain the spectrin cytoskeleton assembly and cell growth. PMID: 15020714
    10. Egl interacts directly with dynein light chain, a microtubule motor component, through an Egl domain distinct from that which binds BicD; data provide a direct link between a molecule necessary for oocyte specification and the microtubule motor complex PMID: 15077115
    11. In addition to verifying binding and mapping interaction sites, the results demonstrate that Drosophila LC8 binding causes substantial changes in stability and quaternary structure of Drosophila protein swallow. PMID: 15078108
    12. the cytoplasmic Dynein-light-chain (DDLC1) which is the cargo-binding subunit of the Dynein motor protein, directly bound with high specificity and affinity to a 230-nucleotide region within the 3'UTR of gurken PMID: 17561283
    13. binding of LC8 to Swallow serves another function, possibly that of a dimerization engine, which is independent of its role in dynein PMID: 17570393
    14. Investigation by NMR ib the effects of a small perturbation by way of a single point mutation, S88A, on the structure, dynamics, and cargo binding efficacy of the DLC8. PMID: 18465876
    15. LC8 dimerization is required to bind to Pak1 and precludes phosphorylation of LC8 at Ser(88). PMID: 18650427
    16. Dynein-dynactin plays a role in excluding dendritic Dscam from axons by retrograde transport. PMID: 18946501

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Dynein light chain family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG6998

    STRING: 7227.FBpp0070672

    UniGene: Dm.5892



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