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  4. Recombinant Drosophila melanogaster Dosage compensation regulator (mle), partial

Recombinant Drosophila melanogaster Dosage compensation regulator (mle), partial

  • 中文名稱：
    黑腹果蠅mle重組蛋白
  • 貨號：
    CSB-YP333021DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅mle重組蛋白
  • 貨號：
    CSB-EP333021DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅mle重組蛋白
  • 貨號：
    CSB-EP333021DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅mle重組蛋白
  • 貨號：
    CSB-BP333021DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅mle重組蛋白
  • 貨號：
    CSB-MP333021DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    mle
  • Uniprot No.：
  • 別名：
    mle; nap; CG11680; Dosage compensation regulator; EC 3.6.4.13; ATP-dependent RNA helicase mle; Protein male-less; Protein maleless; Protein no action potential
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Required in males for dosage compensation of X chromosome linked genes. Mle, msl-1 and msl-3 are colocalized on X chromosome. Each of the msl proteins requires all the other msls for wild-type X-chromosome binding. Probably unwinds double-stranded DNA and RNA in a 3' to 5' direction.
  • 基因功能參考文獻：
    1. We have employed a systems biology approach (microarray) to investigate the global aneuploid effect of the maleless (mle) mutation that disrupts the binding of male specific lethal (MSL) proteins that function in dosage compensation. PMID: 27456781
    2. MLE specifically targets hairpin RNAs at their site of transcription. The association of MLE at these sites is independent of sequence and chromosome location PMID: 26752049
    3. The Drosophila Helicase MLE is Implicated in Functions Distinct From its Role in Dosage Compensation PMID: 25776889
    4. Structure of the RNA Helicase MLE Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling. PMID: 26545078
    5. UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation. PMID: 25158899
    6. Study reports that mle (napts) mutant flies exhibit developmental lethality, decreased fecundity and increased neurodegeneration. PMID: 22513411
    7. Data suggest that MLE can stimulate the transcription activity of rox2 and that MLE associates with rox2 through direct interaction with a newly identified 54-bp repeat, Prox. PMID: 15358781
    8. Zn72D is required for productive splicing of the transcript for the MSL protein Maleless, explaining the dosage compensation defect. PMID: 17923683
    9. the ATPase activity is sufficient for MLE's role in transcriptional enhancement, while the helicase activity is necessary for the spreading of the complex along the X chromosome PMID: 18039854
    10. A maleless structure-function analysis clarified the domain requirements for RNA interaction, helicase activity and localization to the X chromosomal territory. PMID: 18086708
    11. the minimal transactivation domain of MLE mediates the expression of MLE target genes through recruitment of Pol II PMID: 18360693

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  • 亞細胞定位：
    Nucleus. Chromosome. Note=Mle is associated with hundreds of discrete sites along the length of the X chromosome in males and not in females, and is associated with 30-40 autosomal sites in both sexes.
  • 蛋白家族：
    DEAD box helicase family, DEAH subfamily
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG11680

    STRING: 7227.FBpp0085367

    UniGene: Dm.2901



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