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  4. Recombinant Drosophila melanogaster Cytokine receptor (dome), partial

Recombinant Drosophila melanogaster Cytokine receptor (dome), partial

  • 中文名稱：
    黑腹果蠅dome重組蛋白
  • 貨號：
    CSB-YP894285DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅dome重組蛋白
  • 貨號：
    CSB-EP894285DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅dome重組蛋白
  • 貨號：
    CSB-EP894285DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅dome重組蛋白
  • 貨號：
    CSB-BP894285DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅dome重組蛋白
  • 貨號：
    CSB-MP894285DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    dome
  • Uniprot No.：
  • 別名：
    dome; CG14226Cytokine receptor; Protein domeless
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Critical for epithelial morphogenesis during oogenesis; border cell migration. Required in the germarium for the polarization of follicle cells during encapsulation of germline cells. Required for embryonic segmentation and trachea specification. Essential receptor molecule for upd and JAK/STAT signaling during oogenesis.
  • 基因功能參考文獻：
    1. ectopic expression of Wdp inhibits JAK/STAT signaling activity. Importantly, we show that Wdp interacts with the receptor Domeless (Dome), and promotes its internalization for subsequent lysosomal degradation PMID: 25923769
    2. Drosophila epithelia lacking Hrs and Stam, accumulate Dome in endosomes. PMID: 24718108
    3. Data indicate that Domeless is an essential receptor molecule for Upd and JAK/STAT signaling during oogenesis. PMID: 12403714
    4. ligand-independent dimerisation of the JAK/STAT receptor DOME confers cells with competence to activate the pathway prior to ligand reception PMID: 12783781
    5. Awd mutant clones in the main-body follicle cells exhibited significant overaccumulation of Dome, confirming that Awd is a negative regulator of Dome expression. PMID: 18212059

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  • 亞細胞定位：
    Apicolateral cell membrane; Single-pass type I membrane protein. Note=Apicolateral membranes in follical cells.
  • 蛋白家族：
    Type I cytokine receptor family
  • 組織特異性：
    In stage 11 embryos, tracheal pits show highest expression, at stage 14 high expression is detected in the posterior spiracles, gut and head.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG14226

    STRING: 7227.FBpp0074525

    UniGene: Dm.2836



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