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  4. Recombinant Drosophila melanogaster Centrosomin (cnn), partial

Recombinant Drosophila melanogaster Centrosomin (cnn), partial

  • 中文名稱：
    Recombinant Drosophila melanogaster Centrosomin(cnn) ,partial
  • 貨號：
    CSB-YP346968DLU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Centrosomin(cnn) ,partial
  • 貨號：
    CSB-EP346968DLU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Centrosomin(cnn) ,partial
  • 貨號：
    CSB-EP346968DLU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Centrosomin(cnn) ,partial
  • 貨號：
    CSB-BP346968DLU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Centrosomin(cnn) ,partial
  • 貨號：
    CSB-MP346968DLU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    cnn
  • Uniprot No.：
  • 別名：
    cnn; Arr; CG4832Centrosomin; Protein arrow
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Core component of the centrosome throughout spermatogenesis. May participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. Is a target of several homeotic genes.
  • 基因功能參考文獻：
    1. Drosophila centrosomin (cnn) expresses two major protein variants: the centrosomal form (CnnC) and a non-centrosomal form in testes (CnnT). CnnC is established as essential for functional centrosomes, the major MTOCs in animal cells. CnnT is expressed exclusively in testes and localizes to giant mitochondria in spermatids. PMID: 28669756
    2. suggest an expanded model where during interphase CM2 interacts with pericentrin-like-protein to form a layer of centrosomin around the centriole wall and that at the onset of mitosis this population acts as a nucleation site of intramolecular centrosomin interactions that support the expansion into the metaphase matrix PMID: 29315319
    3. Study shows that cnn exon1A-encoded proteins interact with Polo at 2 residues and that this interaction is required for polar body and pericentriolar matrix formation in syncytial embryos. PMID: 27096551
    4. During pericentriolar matrix formation exon 1A Cnn-Long Form proteins likely bind Polo kinase before phosphorylation by Polo for Cnn transport to the centrosome. PMID: 26447129
    5. The findings reveal that polarized targeting of Centrosomin to Golgi outposts during elaboration of the dendrite arbor creates a local system for guiding microtubule polymerization. PMID: 26322925
    6. Cnn and PLP directly interact at two defined sites to coordinate the cell cycle-dependent rearrangement and scaffolding activity of the centrosome to permit normal centrosome organization, cell division, and embryonic viability. PMID: 26150390
    7. Data suggest that centrioles can control the amount of pericentriolar material (PCM) they organize by regulating the rate of Cnn incorporation into the PCM. PMID: 21145741
    8. Data suggest that centrosome size asymmetry in Drosophila neuroblasts is generated by the differential regulation of Cnn incorporation into the PCM at mother and daughter centrioles. PMID: 21145745
    9. characterization of a new class of Cnn short isoforms required for centrosome function during gametogenesis and embryogenesis;evidence for a complex mix of Cnn isoforms present during early embryogenesis PMID: 19528326
    10. centrosomes eject particles of centrosomin-containing pericentriolar material that move on dynamic astral microtubules at a rate that varies with the cell cycle PMID: 12415014
    11. Results suggest that Aurora-A regulates centrosome assembly by controlling centrosomin's (CNN) ability to target and/or anchor gamma-tubulin to the centrosome and to organize microtubule-nucleating sites via interaction with CNN. PMID: 12939255
    12. Cnn Motif 1 is necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes PMID: 17671162
    13. Data suggest that centrosomin maintains the proper connection between the centrioles and the pericentriolar matrix, which is required for accurate centriole segregation in somatic cells but is not essential for the asymmetric division of neuroblasts. PMID: 17709428

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, flagellum basal body. Note=Localized to the centrosomes through complete nuclear cycles in mitotic and meiotic cells. Redistributed into the cytoplasm in G2 phase cells. In post-meiotic stages, found associated with the basal body of the maturing spermatid.
  • 組織特異性：
    Developing visceral mesoderm of the midgut, the central and peripheral nervous system, and developing gonads. Isoform J: Expressed in ovaries, testis and embryos. Isoform A: Expressed in testis only.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG4832

    STRING: 7227.FBpp0301625

    UniGene: Dm.4773



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