在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Drosophila melanogaster Casein kinase I isoform alpha (CkIalpha)

  • 中文名稱:
    Recombinant Drosophila melanogaster Casein kinase I isoform alpha(CkIalpha)
  • 貨號:
    CSB-YP006065DLU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Drosophila melanogaster Casein kinase I isoform alpha(CkIalpha)
  • 貨號:
    CSB-EP006065DLU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Drosophila melanogaster Casein kinase I isoform alpha(CkIalpha)
  • 貨號:
    CSB-EP006065DLU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Drosophila melanogaster Casein kinase I isoform alpha(CkIalpha)
  • 貨號:
    CSB-BP006065DLU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Drosophila melanogaster Casein kinase I isoform alpha(CkIalpha)
  • 貨號:
    CSB-MP006065DLU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    CkIalpha
  • Uniprot No.:
  • 別名:
    CkIalpha; CKI; CG2028; Casein kinase I isoform alpha; CKI-alpha; DmCK1; EC 2.7.11.1
  • 種屬:
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-337
  • 氨基酸序列
    MDKMRILKES RPEIIVGGKY RVIRKIGSGS FGDIYLGMSI QSGEEVAIKM ESAHARHPQL LYEAKLYRIL SGGVGFPRIR HHGKEKNFNT LVMDLLGPSL EDLFNFCTRH FTIKTVLMLV DQMIGRLEYI HLKCFIHRDI KPDNFLMGIG RHCNKLFLID FGLAKKFRDP HTRHHIVYRE DKNLTGTARY ASINAHLGIE QSRRDDMESL GYVMMYFNRG VLPWQGMKAN TKQQKYEKIS EKKMSTPIEV LCKGSPAEFS MYLNYCRSLR FEEQPDYMYL RQLFRILFRT LNHQYDYIYD WTMLKQKTHQ GQPNPAILLE QLDKDKEKQN GKPLIAD
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Negative regulator of wg signaling. Phosphorylates arm directly or indirectly and stimulates its degradation which prevents inappropriate wg signaling. Phosphorylates smo which promotes its accumulation at the cell surface and its signaling activity in response to hh. Together with dco, regulates proteolytic processing of ci by phosphorylating it which promotes its binding to slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin-protein ligase required for ci processing. Inhibits condensin II interphase activity by promoting degradation of the Cap-H2 regulatory subunit and limiting the levels of chromatin-bound Cap-H2 which regulates interphase chromosome organization.
  • 基因功能參考文獻:
    1. glucose regulatory role PMID: 25994086
    2. we identify Casein Kinase I alpha (CK1alpha) as an additional negative-regulator of Cap-H2. CK1a-depletion stabilizes Cap-H2 protein and results in an accumulation of Cap-H2 on chromosomes. PMID: 25723539
    3. Expected genes in the Scar-Arp2/3 actin nucleation pathway were identified as well as casein kinase I, which had a similar morphological RNAi signature. PMID: 21041442
    4. CKI(Casein kinase I) functions as a negative regulator of Arm protein, by phosphorylating it on Ser and Thr residues in the N-terminus and targeting it for degradation. PMID: 11927557
    5. 2 proteins reported to function in Wingless(Wg) signaling identified as Hh pathway components: Dally-like protein required for Hh signal reception, and casein kinase 1alpha, a candidate tumor suppressor that regulates activities of both Hh and Wg pathways PMID: 12663920
    6. expression of doubletime in Drosophila S2 cells produced a CKI-7-sensitive kinase activity which was reduced by both the dbt(S) and dbt(L) mutations of circadian rhythm PMID: 14701759
    7. doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity PMID: 14759367
    8. Several CKI isoforms including CKIalpha and Gish/CKIgamma can phosphorylate the Wg coreceptor Arrow (Arr), which may account, at least in part, for their positive roles in the Wg pathway. PMID: 16987508

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily
  • 數據庫鏈接:

    KEGG: dme:Dmel_CG2028

    STRING: 7227.FBpp0073513

    UniGene: Dm.2166



主站蜘蛛池模板: √最新版天堂资源在线| 亚洲日韩国产av无码无码精品| 中国少妇无码专区| 亚洲 日韩 国产 中文有码| 伊人伊成久久人综合网996| 国产精品星空无限传媒| 三级网站视频在在线播放| 亚洲日韩国产av无码无码精品 | 天堂8а√中文在线官网| 精品一区国产vr| 性欧美熟妇videofreesex| 国产剧情麻豆女教师在线观看| 婷婷网亚洲色偷偷男人的天堂| 精品国产卡一卡2卡3卡| 亚洲性啪啪无码av天堂| 丰满多毛的大隂户毛茸茸| 国产原创av中文在线观看| 思思99热久久精品在线6| 爱做久久久久久| 国产一区二区三区在线蜜桃| 国产精品午夜成人免费观看| 一本久道中文无码字幕av| 国语国产精精品国产国语清晰对话 | 国产亚洲熟妇综合视频| 人妻少妇熟女javhd| 国产成人精品视频一区二区不卡| 国产成+人+综合+亚洲欧美丁香花| 色哟哟免费视频播放网站| 女人另类牲交zozozo| 少妇人妻系列无码专区视频| 国产精品亚洲w码日韩中文| 日本少妇浓毛bbwbbwbbw| 成人做爰69片免费看网站野花| 久热在线中文字幕色999舞| 国产粉嫩小泬在线观看泬| 羞羞影院午夜男女爽爽免费| 亚洲爆乳无码专区| 高h猛烈失禁潮喷无码视频| 欧洲女人性开放免费网站| 自拍偷在线精品自拍偷免费| 欧美激情在线播放|