在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Drosophila melanogaster Brain tumor protein (brat), partial

  • 中文名稱:
    Recombinant Drosophila melanogaster Brain tumor protein(brat),partial
  • 貨號:
    CSB-EP839760DLU
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    brat
  • Uniprot No.:
  • 種屬:
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    26
  • 表達區域:
    294-487aa
  • 氨基酸序列
    QANSQEQQREDSIYGSLHPQQQQQQQQQQQRQLFCPRHKQELLKFSCRTCCILVCKECIVLEHSTGLHELENVQSPGMTTSTGSTANESALQTLLADMRGKIGEIVGIAGNSDQNLTKVKLQYQKAHNELNETHQFFASMLDERKTELLKELETLYTAKVNSNNSWQQRSRDLIDKGLATCEAVERSPAPPSSL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    A NHL-domain family protein that functions a translational repressor to inhibit cell proliferation. Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR. Probably recruited by other proteins to repress translation of other mRNAs in other tissues. Involved in the regulation of ribosomal RNA synthesis and cell growth. Participates in abdominal segmentation and imaginal disk development. During neuroblast division, segregates asymmetrically and inhibits self-renewal of one of the two daughter cells. Together with the asymmetrically segregating transcription factor prospero ensures that the daughter cell will stop growing, exit the cell cycle, and differentiate into neurons possibly by modulating the function of dm in ganglion mother cells (GMC). Restrics developmental potential of type II intermediary neuronal progenitor (INP) cells playing a role in proliferation and maturation of the neuroblasts.
  • 基因功能參考文獻:
    1. Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor proteins has been described. PMID: 28318367
    2. Data suggest that brain tumor protein (Brat) promotes midline crossing through directing the localization or stability of Adenomatous polyposis coli-2 (Apc2) at the plus ends of microtubules in navigating commissural axons. PMID: 29617376
    3. results support a novel role for Brat/TRIM3 in maintaining stem cell equilibrium and suppressing tumor growth by regulating NICD nuclear transport PMID: 26893479
    4. BRAT is a prominent post-transcriptional regulator in the early embryo through mechanisms that are largely independent of PUM. PMID: 25962635
    5. that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction PMID: 25297111
    6. the Brat-dependent mechanism extinguishes the function of the self-renewal factor Klu in the presumptive intermediate progenitor cell by attenuating Arm activity, balancing stem cell maintenance and progenitor cell specification. PMID: 24257623
    7. These results together reveal an important and previously unidentified role for Brat in synaptic development and endocytosis mediated by suppression of BMP signaling. PMID: 23884941
    8. Cofactors Brain Tumor and eIF4E Homologous Protein are not obligatory for Pumilio and Nanos activity. PMID: 22064486
    9. Brain Tumor (Brat) was identified as a potent differentiation factor and target of Pum-Nos regulation. PMID: 21238926
    10. We show that Drosophila larval neuroblasts-stem cell-like precursors of the adult brain-regulate proliferation by segregating the growth inhibitor Brat and the transcription factor Prospero into only one daughter cell. PMID: 16564014
    11. Results suggest that the tumour suppressor brat negatively regulates cell proliferation during larval brain development in Drosophila, and that Prospero acts as a key downstream effector of brat in cell fate specification and proliferation control. PMID: 16774999

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cell cortex.
  • 組織特異性:
    Expressed during embryogenesis, mainly in nervous tissues. Expressed in the embryonic central and peripheral nervous systems including the embryonic brain. In third instar larva it is expressed in the larval central nervous system including the brain and
  • 數據庫鏈接:

    KEGG: dme:Dmel_CG10719

    STRING: 7227.FBpp0293081

    UniGene: Dm.6426



主站蜘蛛池模板: 欧美亚洲日韩国产综合电影| 爱做久久久久久| 夜夜高潮夜夜爽夜夜爱| 日日澡夜夜澡人人高潮| 暖暖视频日本在线观看| 成人免费视频在线观看| 女人裸露免费视频无遮挡网站 | 亚洲综合色区中文字幕| 国产日韩av免费无码一区二区三区| 老妇女性较大毛片| 免费国产黄网站在线观看视频| 日韩丝袜欧美人妻制服| 国产麻豆md传媒视频| 老熟女乱子伦| 少妇人妻丰满做爰xxx| av电影在线观看| 最新 国产 精品 精品 视频| 欧美影视精品久久| 97久久婷婷五月综合色d啪蜜芽| 一本久久a久久免费精品不卡| 欧美黑人xxxx又粗又长| 国产精品久久久久久久久久久久午衣片 | 国语自产精品视频在 视频| 18禁黄网站禁片免费观看国产| 日本牲交大片免费观看| 国产高清成人免费视频在线观看| 亚洲日韩乱码一区二区三区四区| 337p日本欧洲亚洲大胆张筱雨| 亚洲国产成人久久一区| 久久国内精品自在自线| 国内精品自在自线| 亚洲大码熟女在线| 久国产精品人妻aⅴ| 性xxxx欧美老妇506070| 99久久免费国产精品四虎| 69久久国产露脸精品国产| 少妇一边呻吟一边说使劲视频| 免费人成激情视频在线观看冫 | 亚洲精品乱码久久久久久日本麻豆| 人妻夜夜爽天天爽| 日韩综合夜夜香内射|