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  4. Recombinant Drosophila melanogaster Bloom syndrome protein homolog (mus309), partial

Recombinant Drosophila melanogaster Bloom syndrome protein homolog (mus309), partial

  • 中文名稱：
    Recombinant Drosophila melanogaster Bloom syndrome protein homolog(mus309) ,partial
  • 貨號：
    CSB-YP896091DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Bloom syndrome protein homolog(mus309) ,partial
  • 貨號：
    CSB-EP896091DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Bloom syndrome protein homolog(mus309) ,partial
  • 貨號：
    CSB-EP896091DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Bloom syndrome protein homolog(mus309) ,partial
  • 貨號：
    CSB-BP896091DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Bloom syndrome protein homolog(mus309) ,partial
  • 貨號：
    CSB-MP896091DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Blm
  • Uniprot No.：
  • 別名：
    Blm; mus309; CG6920Bloom syndrome protein homolog; Dmblm; EC 3.6.4.12; Bloom syndrome helicase ortholog; Mutagen-sensitive protein 309; RecQ helicase homolog
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.; ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Negatively regulates sister chromatid exchange (SCE). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction.
  • 基因功能參考文獻：
    1. Study shows that meiotic crossover patterning is lost in Drosophila melanogaster mutants that lack the Bloom syndrome helicase. PMID: 27989672
    2. Blm helicase function plays a role in homologous recombination. Blm is not required for suppression of recombination between diverged sequences. PMID: 28912341
    3. Dme-miR-314-3p modulation in Cr(VI) exposed Drosophila affects DNA damage repair by targeting mus309 PMID: 26590872
    4. Drosophila BLM suppresses error-prone alternative end-joining repair of DNA double-strand breaks that can result in genome instability and tumor formation during aging. PMID: 22183041
    5. these studies of synthetic lethality provide insights into the multiple functions of DmBLM and how various endonucleases may function when DmBLM is absent PMID: 22022278
    6. Data show that excision screens in mus309 mutant flies that lack DmBlm increases the percentage and overall size of flanking deletions recovered after excision of either P or Minos elements. PMID: 19687136
    7. Coding sequence of Ku70 gene is wild-type in two mus309 mutant lines. PMID: 12206368
    8. results suggest a model in which BLM maintains genomic stability by promoting efficient repair DNA synthesis and thereby prevents double-strand break repair by less precise pathways PMID: 12522255
    9. model in which DmBlm acts downstream of strand invasion to unwind a D-loop intermediate to free the newly synthesized strand PMID: 15501916
    10. Blm mutants are defective for homologous repair but show a compensating increase in single-strand annealing. PMID: 17075047
    11. DmBLM combines DNA strand displacement with DNA strand annealing to catalyze the displacement of one DNA strand while annealing a second complementary DNA strand. PMID: 17272294
    12. Mutations that delete the N terminus of DmBlm, but not the helicase domain, have DSB repair defects as severe as those caused by null mutations. PMID: 17507683
    13. mutations in mus81 and mms4 are synthetically lethal with null mutations in mus309 PMID: 17603121
    14. The suppression of homeologous single strand annealing depends on the Bloom helicase (Blm), encoded by the Drosophila gene mus309. PMID: 18978019

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Helicase family, RecQ subfamily
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG6920

    STRING: 7227.FBpp0081910

    UniGene: Dm.2444



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