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  4. Recombinant Drosophila melanogaster ATP-dependent RNA helicase bel (bel), partial

Recombinant Drosophila melanogaster ATP-dependent RNA helicase bel (bel), partial

  • 中文名稱：
    Recombinant Drosophila melanogaster ATP-dependent RNA helicase bel(bel) ,partial
  • 貨號：
    CSB-YP893283DLU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster ATP-dependent RNA helicase bel(bel) ,partial
  • 貨號：
    CSB-EP893283DLU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster ATP-dependent RNA helicase bel(bel) ,partial
  • 貨號：
    CSB-EP893283DLU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster ATP-dependent RNA helicase bel(bel) ,partial
  • 貨號：
    CSB-BP893283DLU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster ATP-dependent RNA helicase bel(bel) ,partial
  • 貨號：
    CSB-MP893283DLU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    bel
  • Uniprot No.：
  • 別名：
    bel; CG9748ATP-dependent RNA helicase bel; EC 3.6.4.13; Protein belle
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    ATP-dependent RNA helicase that is essential and required for cellular function, larval growth, and for male and female fertility. Also required for RNA interference (RNAi), double-stranded RNA induces potent and specific gene silencing, by acting downstream of dsRNA internalization. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger.
  • 基因功能參考文獻：
    1. Bel is required for nos mRNA translational repression. PMID: 28701521
    2. DDX3/Belle Exerts Its Function Outside of the Wnt/Wingless Signaling Pathway PMID: 28030561
    3. show that genetic inhibition of Bel function leads to de novo generation of piRNAs from the transgene region inserted in the genome, suggesting a potential piRNA-dependent mechanism that may mediate transgene silencing as Bel function is inhibited PMID: 26900887
    4. Results suggest that a role of RNA helicase Belle in germline stem cells (GSCs) and maintenance and germline stem cells (GSCs)regulation of early germ cell divisions. PMID: 26876306
    5. findings show that the belle (bel) mRNA is translationally repressed by the d4EHP protein in the Drosophila ovary. Consistent with this regulation, d4EHP overexpression in the ovary phenocopies the bel mutant. PMID: 21788736
    6. DEAD-box RNA helicase Belle and the RNA interference pathway promote mitotic chromosome segregation. PMID: 21730191
    7. Belle might be functioning in the microRNA pathway in follicle cells. PMID: 21447549
    8. Inactivation of bel renders cells less sensitive to several anti-proliferative signals inducing G1 arrest. PMID: 20160476

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  • 亞細胞定位：
    Cytoplasm. Note=In nurse cells, follicle cells, and within the oocyte. Vas and bel colocalize in the perinuclear region of nurse cells.
  • 蛋白家族：
    DEAD box helicase family, DDX3/DED1 subfamily
  • 組織特異性：
    Vas and bel colocalize in nuage (perinuclear, electron-dense granules in germline cells) and at the oocyte posterior during oogenesis.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG9748

    STRING: 7227.FBpp0081374

    UniGene: Dm.7823



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